Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 23584..24239 | Replicon | plasmid pCT02021853_74 |
| Accession | NC_011204 | ||
| Organism | Salmonella enterica subsp. enterica serovar Dublin str. CT 02021853 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | M7RF18 |
| Locus tag | SED_RS00155 | Protein ID | WP_000812999.1 |
| Coordinates | 23811..24239 (+) | Length | 143 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | H9AC95 |
| Locus tag | SED_RS00150 | Protein ID | WP_001261283.1 |
| Coordinates | 23584..23814 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SED_RS24190 | 19122..19458 | - | 337 | Protein_21 | hypothetical protein | - |
| SED_RS00115 | 19452..19961 | - | 510 | WP_001541544.1 | CaiF/GrlA family transcriptional regulator | - |
| SED_RS00120 | 19965..20678 | - | 714 | WP_000545756.1 | EAL domain-containing protein | - |
| SED_RS00125 | 20687..21469 | - | 783 | WP_000082169.1 | site-specific integrase | - |
| SED_RS00130 | 21504..22025 | - | 522 | WP_000198608.1 | hypothetical protein | - |
| SED_RS00135 | 22022..22312 | - | 291 | WP_001266176.1 | hypothetical protein | - |
| SED_RS00140 | 22314..22619 | - | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | - |
| SED_RS00145 | 22621..22839 | - | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| SED_RS00150 | 23584..23814 | + | 231 | WP_001261283.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| SED_RS00155 | 23811..24239 | + | 429 | WP_000812999.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| SED_RS00160 | 24809..25657 | - | 849 | WP_000175391.1 | SdiA-regulated domain-containing protein | - |
| SED_RS26545 | 25683..25844 | - | 162 | WP_001816720.1 | hypothetical protein | - |
| SED_RS00165 | 26105..26317 | - | 213 | WP_000063794.1 | hypothetical protein | - |
| SED_RS00170 | 26390..26974 | - | 585 | WP_001575501.1 | hypothetical protein | - |
| SED_RS00175 | 27099..27812 | - | 714 | WP_000801115.1 | hypothetical protein | - |
| SED_RS00180 | 27812..28087 | - | 276 | WP_001020576.1 | hypothetical protein | - |
| SED_RS00185 | 28074..28838 | - | 765 | WP_000827659.1 | K88 minor fimbrial subunit faeI | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..74551 | 74551 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 143 a.a. Molecular weight: 18346.91 Da Isoelectric Point: 12.9522
>T23054 WP_000812999.1 NC_011204:23811-24239 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853]
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Download Length: 429 bp
>T23054 NC_011204:23811-24239 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853]
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Antitoxin
Download Length: 77 a.a. Molecular weight: 9887.42 Da Isoelectric Point: 12.6808
>AT23054 WP_001261283.1 NC_011204:23584-23814 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853]
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Download Length: 231 bp
>AT23054 NC_011204:23584-23814 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | M7RF18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6X6R7C5 |