230538

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2781741..2782269 Replicon chromosome
Accession NZ_CP090382
Organism Acinetobacter towneri strain SCLZS30

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LZG54_RS13390 Protein ID WP_234114194.1
Coordinates 2781976..2782269 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9B5Q7
Locus tag LZG54_RS13385 Protein ID WP_000246756.1
Coordinates 2781741..2781986 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG54_RS13365 (LZG54_13380) 2777661..2778365 + 705 WP_160255362.1 IS6-like element IS1006 family transposase -
LZG54_RS13370 (LZG54_13385) 2778514..2779080 - 567 WP_000678311.1 recombinase family protein -
LZG54_RS13375 (LZG54_13390) 2779586..2781040 - 1455 WP_234114193.1 SulP family inorganic anion transporter -
LZG54_RS13380 (LZG54_13395) 2781290..2781499 - 210 WP_004976362.1 hypothetical protein -
LZG54_RS13385 (LZG54_13400) 2781741..2781986 + 246 WP_000246756.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LZG54_RS13390 (LZG54_13405) 2781976..2782269 + 294 WP_234114194.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZG54_RS13395 (LZG54_13410) 2782354..2782689 + 336 WP_035363642.1 hypothetical protein -
LZG54_RS13400 (LZG54_13415) 2782739..2782918 + 180 WP_016658770.1 hypothetical protein -
LZG54_RS13405 (LZG54_13420) 2782915..2783301 + 387 WP_004769969.1 type II toxin-antitoxin system death-on-curing family toxin -
LZG54_RS13410 (LZG54_13425) 2783303..2783854 - 552 WP_234114195.1 macro domain-containing protein -
LZG54_RS13415 (LZG54_13430) 2783860..2784573 - 714 WP_218955725.1 hypothetical protein -
LZG54_RS13420 (LZG54_13435) 2784753..2785541 + 789 Protein_2592 ISNCY family transposase -
LZG54_RS13425 (LZG54_13440) 2785613..2786688 + 1076 WP_234114182.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2773591..2789198 15607
- inside IScluster/Tn - - 2765069..2778365 13296


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-71)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11322.55 Da        Isoelectric Point: 10.4753

>T230538 WP_234114194.1 NZ_CP090382:2781976-2782269 [Acinetobacter towneri]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRTDSIVYDEAKKRIKD

Download         Length: 294 bp

>T230538 NZ_CP124921:c317826-317731 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCTATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9235.61 Da        Isoelectric Point: 4.3142

>AT230538 WP_000246756.1 NZ_CP090382:2781741-2781986 [Acinetobacter towneri]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT230538 NZ_CP124921:317631-317696 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB N9B5Q7

References