230537

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2772573..2773101 Replicon chromosome
Accession NZ_CP090382
Organism Acinetobacter towneri strain SCLZS30

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LZG54_RS13330 Protein ID WP_234114192.1
Coordinates 2772573..2772866 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1E8DZ10
Locus tag LZG54_RS13335 Protein ID WP_026438268.1
Coordinates 2772856..2773101 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG54_RS13290 (LZG54_13305) 2768781..2769116 - 336 WP_171430713.1 IS66 family insertion sequence element accessory protein TnpB -
LZG54_RS13295 (LZG54_13310) 2769113..2769496 - 384 WP_234114191.1 transposase -
LZG54_RS13300 (LZG54_13315) 2769582..2770015 - 434 Protein_2568 IS3 family transposase -
LZG54_RS13305 (LZG54_13320) 2770432..2770746 - 315 WP_038350244.1 BrnA antitoxin family protein -
LZG54_RS13310 (LZG54_13325) 2770709..2771020 - 312 WP_038350243.1 BrnT family toxin -
LZG54_RS13315 (LZG54_13330) 2771339..2771665 - 327 WP_005108845.1 hypothetical protein -
LZG54_RS13320 (LZG54_13335) 2771655..2772086 - 432 WP_018680121.1 hypothetical protein -
LZG54_RS13325 (LZG54_13340) 2772193..2772507 + 315 WP_005108843.1 hypothetical protein -
LZG54_RS13330 (LZG54_13345) 2772573..2772866 - 294 WP_234114192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZG54_RS13335 (LZG54_13350) 2772856..2773101 - 246 WP_026438268.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LZG54_RS13340 (LZG54_13355) 2773260..2774507 + 1248 Protein_2576 IS3 family transposase -
LZG54_RS13345 (LZG54_13360) 2774730..2775230 - 501 WP_019838469.1 YqhA family protein -
LZG54_RS13350 (LZG54_13365) 2775537..2775629 - 93 Protein_2578 hypothetical protein -
LZG54_RS13355 (LZG54_13370) 2775677..2776381 - 705 WP_160255362.1 IS6-like element IS1006 family transposase -
LZG54_RS13360 (LZG54_13375) 2776609..2777583 + 975 WP_019838459.1 calcium/sodium antiporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2773591..2789198 15607
- inside IScluster/Tn - - 2765069..2778365 13296


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-74)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11238.39 Da        Isoelectric Point: 10.3743

>T230537 WP_234114192.1 NZ_CP090382:c2772866-2772573 [Acinetobacter towneri]
MTYNLLRHKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLKGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T230537 NZ_CP124920:42155-42265 [Enterococcus faecalis]
GTGTTATTTGTGAAAGATTTAATGTCGTTGGTTATCGCACCGATCTTTGTAGGATTGGTTCTGGAAATGATTTCTCGTGT
GTTGGACGAGGAAGACGATAACCGAAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9248.61 Da        Isoelectric Point: 4.2821

>AT230537 WP_026438268.1 NZ_CP090382:c2773101-2772856 [Acinetobacter towneri]
MATVNFRVDEALKEKSYSILKEQGIAPTEFFTNILEYIATTGKLPVQKALLSEEDTELLAIVRKRVNDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT230537 NZ_CP124920:c42369-42305 [Enterococcus faecalis]
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1E8DZ10

References