Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1689531..1690163 Replicon chromosome
Accession NZ_CP090382
Organism Acinetobacter towneri strain SCLZS30

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LZG54_RS08105 Protein ID WP_178318372.1
Coordinates 1689531..1689935 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LZG54_RS08110 Protein ID WP_178318371.1
Coordinates 1689936..1690163 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG54_RS08085 (LZG54_08100) 1684653..1684793 + 141 Protein_1566 IS5/IS1182 family transposase -
LZG54_RS08090 (LZG54_08105) 1685276..1685887 + 612 WP_005157459.1 hypothetical protein -
LZG54_RS08095 (LZG54_08110) 1686052..1687692 + 1641 WP_178318374.1 dynamin family protein -
LZG54_RS08100 (LZG54_08115) 1687783..1689432 + 1650 WP_234113689.1 dynamin family protein -
LZG54_RS08105 (LZG54_08120) 1689531..1689935 - 405 WP_178318372.1 tRNA(fMet)-specific endonuclease VapC Toxin
LZG54_RS08110 (LZG54_08125) 1689936..1690163 - 228 WP_178318371.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LZG54_RS08115 (LZG54_08130) 1690658..1691469 - 812 Protein_1572 IS4-like element ISAba33 family transposase -
LZG54_RS08120 (LZG54_08135) 1691618..1693747 - 2130 WP_178866593.1 peptidase domain-containing ABC transporter -
LZG54_RS08125 (LZG54_08140) 1693751..1695016 - 1266 WP_178866595.1 HlyD family efflux transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15054.46 Da        Isoelectric Point: 8.0384

>T230535 WP_178318372.1 NZ_CP090382:c1689935-1689531 [Acinetobacter towneri]
MLKYMLDTNIVIYTMKQRPIEVKEKFNAVSTQLCISSISVAELIFGAENSQTPEKNLKIIENFLSRLQILDYGVDAAIQY
GNIKAHLKKIGTPIGENDLHIAAHARSKGLILVTNNTKEFERVPALQIENWVNG

Download         Length: 405 bp

>T230535 NZ_CP124919:11442-11717 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAACAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAACTATTTCGATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8764.86 Da        Isoelectric Point: 4.3466

>AT230535 WP_178318371.1 NZ_CP090382:c1690163-1689936 [Acinetobacter towneri]
MLTSVFMNNRTQAVRLPSIYRFSESTQKVFVRMVGVERVISPVEQVWDSFFDDPDLQLSADFERGEQISTEREAF

Download         Length: 228 bp

>AT230535 NZ_CP124919:11183-11449 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References