Detailed information of TA system TA230534

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1335240..1335814
• Replicon: chromosome
• Accession: NZ_CP090382
• Organism: Acinetobacter towneri strain SCLZS30

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: N9B925
• Locus tag: LZG54_RS06330
• Protein ID: WP_004973562.1
• Coordinates: 1335240..1335428 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LZG54_RS06335
• Protein ID: WP_104851972.1
• Coordinates: 1335431..1335814 (+)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZG54_RS06295 (LZG54_06310)	1330494..1330982	+	489	WP_004973550.1	helix-turn-helix domain-containing protein	-
LZG54_RS06300 (LZG54_06315)	1331013..1331324	-	312	WP_234114928.1	TusE/DsrC/DsvC family sulfur relay protein	-
LZG54_RS06305 (LZG54_06320)	1331379..1331663	-	285	WP_234114929.1	DsrH/TusB family sulfur relay protein	-
LZG54_RS06310 (LZG54_06325)	1331729..1332079	-	351	WP_004973555.1	hypothetical protein	-
LZG54_RS06315 (LZG54_06330)	1332123..1332491	-	369	WP_104851975.1	sulfurtransferase complex subunit TusD	-
LZG54_RS06320 (LZG54_06335)	1332553..1333557	+	1005	WP_234114930.1	SDR family NAD(P)-dependent oxidoreductase	-
LZG54_RS06325 (LZG54_06340)	1333713..1335107	+	1395	WP_180051523.1	class II fumarate hydratase	-
LZG54_RS06330 (LZG54_06345)	1335240..1335428	+	189	WP_004973562.1	type II toxin-antitoxin system HicA family toxin	Toxin
LZG54_RS06335 (LZG54_06350)	1335431..1335814	+	384	WP_104851972.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LZG54_RS06340 (LZG54_06355)	1336187..1336678	+	492	WP_180064719.1	hypothetical protein	-
LZG54_RS06345 (LZG54_06360)	1336783..1337700	-	918	WP_234114931.1	LysR family transcriptional regulator	-
LZG54_RS06350 (LZG54_06365)	1337794..1339035	+	1242	WP_004973568.1	acyl-CoA dehydrogenase family protein	-
LZG54_RS06355 (LZG54_06370)	1339166..1340287	+	1122	WP_004973572.1	phosphotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	sul1 / qacE / catB3 / blaOXA-392 / ant(2'')-Ia	-	1115104..1444700	329596

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7350.46 Da
• Isoelectric Point: 10.2954

>T230534 WP_004973562.1 NZ_CP090382:1335240-1335428 [Acinetobacter towneri]
MNSKDIIKRLEQEGWYKVGGKGDHEKYKHPEKPGHVVVPHPRKDMPIGTLRNIYKQAGWEWR

Nucleotide

• Length: 189 bp

>T230534 NZ_CP124918:2807459-2807602 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 14328.16 Da
• Isoelectric Point: 4.3695

>AT230534 WP_104851972.1 NZ_CP090382:1335431-1335814 [Acinetobacter towneri]
MLYPVYVHKDEDSAYGLTFPDFDGCFSAADELQDIQRMAQEAVEVHFDGEDIPLPEPSSPEQWLGDERFEGGFWLLVDID
TTKVNTKSIRINISMPEALVKRIDAVAKKQHLSRSAFLAKSAEMALH

Nucleotide

• Length: 384 bp

>AT230534 NZ_CP124918:c2807796-2807534 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: N9B925