Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2195632..2196146 Replicon chromosome
Accession NZ_CP090375
Organism Staphylococcus aureus strain GD4SA108-1

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LZ178_RS10630 Protein ID WP_000581792.1
Coordinates 2195632..2195841 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag LZ178_RS10635 Protein ID WP_000138932.1
Coordinates 2195853..2196146 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ178_RS10610 (LZ178_10590) 2191143..2192498 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
LZ178_RS10615 (LZ178_10595) 2192513..2193583 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
LZ178_RS10620 (LZ178_10600) 2193901..2195103 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LZ178_RS10625 (LZ178_10605) 2195367..2195504 - 138 WP_000828354.1 Lmo0850 family protein -
LZ178_RS10630 (LZ178_10610) 2195632..2195841 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LZ178_RS10635 (LZ178_10615) 2195853..2196146 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
LZ178_RS10640 (LZ178_10620) 2196312..2197796 + 1485 WP_000571550.1 cardiolipin synthase -
LZ178_RS10645 (LZ178_10625) 2197824..2198471 + 648 WP_001187614.1 HD domain-containing protein -
LZ178_RS10650 (LZ178_10630) 2199028..2199090 + 63 Protein_2056 hypothetical protein -
LZ178_RS10655 (LZ178_10635) 2199068..2200383 - 1316 Protein_2057 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T230508 WP_000581792.1 NZ_CP090375:c2195841-2195632 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T230508 NZ_CP124913:c2668548-2668273 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT230508 WP_000138932.1 NZ_CP090375:c2196146-2195853 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT230508 NZ_CP124913:c2668807-2668541 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References