Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2175895..2176424 Replicon chromosome
Accession NZ_CP090375
Organism Staphylococcus aureus strain GD4SA108-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LZ178_RS10540 Protein ID WP_000621175.1
Coordinates 2175895..2176257 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag LZ178_RS10545 Protein ID WP_000948331.1
Coordinates 2176254..2176424 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ178_RS10520 (LZ178_10500) 2172873..2173643 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
LZ178_RS10525 (LZ178_10505) 2173618..2174097 - 480 WP_001190825.1 anti-sigma B factor RsbW -
LZ178_RS10530 (LZ178_10510) 2174099..2174425 - 327 WP_001052491.1 anti-sigma factor antagonist -
LZ178_RS10535 (LZ178_10515) 2174544..2175545 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
LZ178_RS10540 (LZ178_10520) 2175895..2176257 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LZ178_RS10545 (LZ178_10525) 2176254..2176424 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LZ178_RS10550 (LZ178_10530) 2176509..2177657 - 1149 WP_001281139.1 alanine racemase -
LZ178_RS10555 (LZ178_10535) 2177723..2178082 - 360 WP_000581197.1 holo-ACP synthase -
LZ178_RS10560 (LZ178_10540) 2178086..2178577 - 492 WP_001286980.1 PH domain-containing protein -
LZ178_RS10565 (LZ178_10545) 2178570..2180147 - 1578 WP_001294650.1 PH domain-containing protein -
LZ178_RS10570 (LZ178_10550) 2180140..2180619 - 480 WP_001287081.1 hypothetical protein -
LZ178_RS10575 (LZ178_10555) 2180828..2181388 - 561 WP_001092419.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T230507 WP_000621175.1 NZ_CP090375:c2176257-2175895 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T230507 NZ_CP124913:c2465170-2465054 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT230507 WP_000948331.1 NZ_CP090375:c2176424-2176254 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT230507 NZ_CP124913:2464938-2465143 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTTTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References