Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 970583..971059 Replicon chromosome
Accession NZ_CP090375
Organism Staphylococcus aureus strain GD4SA108-1

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag LZ178_RS04610 Protein ID WP_000052076.1
Coordinates 970583..970771 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag LZ178_RS04615 Protein ID WP_001059690.1
Coordinates 970799..971059 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ178_RS04580 (LZ178_04565) 966092..967264 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
LZ178_RS04585 (LZ178_04570) 967436..968121 + 686 Protein_892 thermonuclease family protein -
LZ178_RS04590 (LZ178_04575) 968478..968678 + 201 WP_001059082.1 cold-shock protein -
LZ178_RS04595 (LZ178_04580) 969175..969393 - 219 WP_000005881.1 hypothetical protein -
LZ178_RS04600 (LZ178_04585) 969454..969738 - 285 WP_001004403.1 hypothetical protein -
LZ178_RS04605 (LZ178_04590) 969826..970395 - 570 WP_001106655.1 lipoprotein N-acylation protein LnsA -
LZ178_RS04610 (LZ178_04595) 970583..970771 - 189 WP_000052076.1 hypothetical protein Toxin
LZ178_RS04615 (LZ178_04600) 970799..971059 - 261 WP_001059690.1 hypothetical protein Antitoxin
LZ178_RS04620 (LZ178_04605) 971401..971604 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
LZ178_RS04625 (LZ178_04610) 971601..971837 - 237 WP_000368687.1 hypothetical protein -
LZ178_RS04630 (LZ178_04615) 972062..972643 + 582 WP_001140696.1 histidine phosphatase family protein -
LZ178_RS04635 (LZ178_04620) 972716..973333 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
LZ178_RS04640 (LZ178_04625) 973482..973976 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
LZ178_RS04645 (LZ178_04630) 974375..974797 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
LZ178_RS04650 (LZ178_04635) 974945..975661 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 966092..967264 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(1-33)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T230505 WP_000052076.1 NZ_CP090375:c970771-970583 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T230505 NZ_CP124913:433332-433433 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT230505 WP_001059690.1 NZ_CP090375:c971059-970799 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT230505 NZ_CP124913:c433556-433378 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References