230502

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 2447419..2448112 Replicon chromosome
Accession NZ_CP090366
Organism Stutzerimonas kunmingensis strain 7850S

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag LW136_RS11550 Protein ID WP_003151133.1
Coordinates 2447419..2447796 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag LW136_RS11555 Protein ID WP_001172026.1
Coordinates 2447777..2448112 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LW136_RS11535 (LW136_11535) 2442697..2443404 + 708 Protein_2266 histidine kinase sensor domain-containing protein -
LW136_RS11540 (LW136_11540) 2443612..2446641 - 3030 WP_010799689.1 Tn3 family transposase -
LW136_RS11545 (LW136_11545) 2446625..2447227 - 603 WP_010465829.1 recombinase family protein -
LW136_RS11550 (LW136_11550) 2447419..2447796 + 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LW136_RS11555 (LW136_11555) 2447777..2448112 + 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
LW136_RS11560 (LW136_11560) 2448127..2448462 + 336 WP_000741275.1 hypothetical protein -
LW136_RS11565 (LW136_11565) 2448486..2448812 + 327 WP_000091614.1 hypothetical protein -
LW136_RS11570 (LW136_11570) 2448828..2449169 + 342 WP_025999701.1 hypothetical protein -
LW136_RS11575 (LW136_11575) 2449210..2449500 + 291 WP_004423344.1 hypothetical protein -
LW136_RS11580 (LW136_11580) 2449497..2449841 + 345 WP_004423345.1 IS66 family insertion sequence element accessory protein TnpB -
LW136_RS11585 (LW136_11585) 2449963..2451501 + 1539 WP_011911868.1 IS66 family transposase -
LW136_RS11590 (LW136_11590) 2451491..2451760 + 270 WP_003458515.1 hypothetical protein -
LW136_RS11595 (LW136_11595) 2451946..2452275 - 330 WP_032489165.1 four-helix bundle copper-binding protein -
LW136_RS11600 (LW136_11600) 2452468..2452554 + 87 Protein_2279 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T230502 WP_003151133.1 NZ_CP090366:2447419-2447796 [Stutzerimonas kunmingensis]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

>T230502 NZ_CP124913:c121621-120983 [Enterococcus faecalis]
ATGATACTAAATAAGAAAAAATTATATTTCGAAACACAGGCATTTACTGACAAACTTATAAATGAAATTTCAATCAATAT
GTCTAAAAGAAAAGAACTCATCAATTGTTATGATATTGAAGCCTACGTAAAAGAAACCGAAAACATTGATTTTTTTGATT
ATCCATTCAAAAAACAATCTAAAAAATTAATCTGGGGATCAGTAACAAAAATTGGTGATGTAACTATGGTAGCGACTGCC
CAACACTTGAAAATAGAAATTAAAAATTTTACGAAAATGCACGAAATAATTCATCATTATTTTGACTATACGACAGATAT
GCCTAACAATGAAAAATCATTTGATACACTACTTATAAAAAAGGGCTATCTTCCTGAAGATTATCCTAAAGAATTCAGAG
CAAATAAGGGTGCCGGAATGTTACTTATTAATAAAAAAGCCTTAAAGTATGCATTTAGTACTTATGATGATCTTGAAAAA
ATGGCTAGTTTTTTCAACGTAAACGATATAGTTCTCAAGATAAGAATTCTTGACGAATTAATCTATTCCCACAACTTATC
TTATAAACAAGCCAATCTTATTTATAATAGTTACTATTTTCAACAACAAACACAACTTAAAGAGATTTTACTCAAATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT230502 WP_001172026.1 NZ_CP090366:2447777-2448112 [Stutzerimonas kunmingensis]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp

>AT230502 NZ_CP124913:c122002-121628 [Enterococcus faecalis]
ATGAAAACTTACGAAAAGATAAAACAATTAAGAGAAAATAGAGAAATCACTCAAAAAGAAATTTCAAACGCACTAGACAT
TAATGTTAGTGTATATAATAAAATAGAACTTGGAATACGTCCATTAAGAGAAGAAGAACTTACTGCTATTGCTGATTTTT
TTAATGTTTCAATTGATTATTTAACAGGACGCACTGATAACCCTACAACACCTTCAAATAATCAAAAAGAAGCTGGACAA
AATATTATTTCACATTTCAGATTAAACACTAATGATTTAAGTTCTGATGACATAGAAGAATTAGAAAAAGAATTGATTGA
TTTTCAAGAATTTCTTATAAAACGAGCAAAAGAAAGAAAAAAAAAGAGTGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References