Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2472873..2473490 Replicon chromosome
Accession NZ_CP090356
Organism Pantoea ananatis strain JBR-LB3-16

Toxin (Protein)


Gene name Hha Uniprot ID D4GLR0
Locus tag LVR30_RS11460 Protein ID WP_013024903.1
Coordinates 2472873..2473088 (-) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A8A4KA49
Locus tag LVR30_RS11465 Protein ID WP_015700827.1
Coordinates 2473113..2473490 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVR30_RS11430 (LVR30_11435) 2468794..2469132 + 339 WP_013024898.1 P-II family nitrogen regulator -
LVR30_RS11435 (LVR30_11440) 2469166..2470455 + 1290 WP_014606435.1 ammonium transporter AmtB -
LVR30_RS11440 (LVR30_11445) 2470502..2471365 - 864 WP_013024900.1 acyl-CoA thioesterase II -
LVR30_RS11445 (LVR30_11450) 2471558..2472115 + 558 WP_013024901.1 YbaY family lipoprotein -
LVR30_RS11450 (LVR30_11455) 2472164..2472475 - 312 WP_014606432.1 MGMT family protein -
LVR30_RS11460 (LVR30_11465) 2472873..2473088 - 216 WP_013024903.1 HHA domain-containing protein Toxin
LVR30_RS11465 (LVR30_11470) 2473113..2473490 - 378 WP_015700827.1 Hha toxicity modulator TomB Antitoxin
LVR30_RS11470 (LVR30_11475) 2473637..2473990 - 354 WP_013024905.1 hypothetical protein -
LVR30_RS11475 (LVR30_11480) 2474345..2475013 + 669 WP_014606429.1 ABC transporter ATP-binding protein -
LVR30_RS11480 (LVR30_11485) 2475010..2475849 + 840 WP_013024907.1 metal ABC transporter permease -
LVR30_RS11485 (LVR30_11490) 2475862..2476740 + 879 WP_013024908.1 metal ABC transporter substrate-binding protein -
LVR30_RS11490 (LVR30_11495) 2476800..2476940 - 141 WP_014606428.1 type B 50S ribosomal protein L36 -
LVR30_RS11495 (LVR30_11500) 2476952..2477206 - 255 WP_014606427.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8552.98 Da        Isoelectric Point: 9.4825

>T230484 WP_013024903.1 NZ_CP090356:c2473088-2472873 [Pantoea ananatis]
MNKTLTKTDYLMRLRRCRSIDTLERVIEKNKYELPDEELAVFYSAADHRLAELTMNKLYDKVPVSVWKFVR

Download         Length: 216 bp

>T230484 NZ_CP124908:c2691958-2691815 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACGGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14722.35 Da        Isoelectric Point: 4.3976

>AT230484 WP_015700827.1 NZ_CP090356:c2473490-2473113 [Pantoea ananatis]
MDEYSPKRHDIAQLKYLCENLFDDSMATLTDSHHGWVNDPTAESNLQLNDLIEHIASFTMNYKIKHVEDEALITQIDEYL
DDTFMLFSNYSVNTQDLQRWQRSAKRLFNVFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT230484 NZ_CP124908:2691696-2691841 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References