230478

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 524907..525543 Replicon chromosome
Accession NZ_CP090354
Organism Bacillus safensis strain H31R-08

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag LXN49_RS02525 Protein ID WP_024425388.1
Coordinates 525193..525543 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag LXN49_RS02520 Protein ID WP_003214273.1
Coordinates 524907..525188 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXN49_RS02500 (LXN49_02500) 521053..521658 - 606 WP_024425384.1 rhomboid family intramembrane serine protease -
LXN49_RS02505 (LXN49_02505) 521753..522118 + 366 WP_041089202.1 holo-ACP synthase -
LXN49_RS02510 (LXN49_02510) 522279..523295 + 1017 WP_087975235.1 outer membrane lipoprotein-sorting protein -
LXN49_RS02515 (LXN49_02515) 523437..524612 + 1176 WP_234107595.1 alanine racemase -
LXN49_RS02520 (LXN49_02520) 524907..525188 + 282 WP_003214273.1 hypothetical protein Antitoxin
LXN49_RS02525 (LXN49_02525) 525193..525543 + 351 WP_024425388.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
LXN49_RS02530 (LXN49_02530) 525660..526490 + 831 WP_044334717.1 RsbT co-antagonist protein RsbRA -
LXN49_RS02535 (LXN49_02535) 526495..526863 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
LXN49_RS02540 (LXN49_02540) 526866..527267 + 402 WP_024425390.1 anti-sigma regulatory factor -
LXN49_RS02545 (LXN49_02545) 527278..528285 + 1008 WP_216100091.1 PP2C family protein-serine/threonine phosphatase -
LXN49_RS02550 (LXN49_02550) 528345..528674 + 330 WP_024425392.1 anti-sigma factor antagonist -
LXN49_RS02555 (LXN49_02555) 528671..529159 + 489 WP_024425393.1 anti-sigma B factor RsbW -
LXN49_RS02560 (LXN49_02560) 529125..529913 + 789 WP_024427378.1 RNA polymerase sigma factor SigB -
LXN49_RS02565 (LXN49_02565) 529913..530512 + 600 WP_024427379.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T230478 WP_024425388.1 NZ_CP090354:525193-525543 [Bacillus safensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T230478 NZ_CP124908:c317819-317724 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCTATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT230478 WP_003214273.1 NZ_CP090354:524907-525188 [Bacillus safensis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT230478 NZ_CP124908:317624-317689 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7G713

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References