Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 290751..291441 Replicon plasmid unnamed1
Accession NZ_CP090350
Organism Methylobacterium oryzae strain H33R-06

Toxin (Protein)


Gene name vapC Uniprot ID A0A1I6WGP9
Locus tag LXM90_RS29800 Protein ID WP_020094418.1
Coordinates 290995..291441 (+) Length 149 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LXM90_RS29795 Protein ID WP_026605131.1
Coordinates 290751..290990 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXM90_RS29770 (LXM90_29770) 286644..286892 - 249 WP_026605132.1 hypothetical protein -
LXM90_RS29775 (LXM90_29775) 287229..287492 - 264 WP_020094423.1 hypothetical protein -
LXM90_RS29780 (LXM90_29780) 288190..288456 + 267 WP_020094422.1 GNAT family N-acetyltransferase -
LXM90_RS29785 (LXM90_29785) 288515..289807 - 1293 WP_234083187.1 TAXI family TRAP transporter solute-binding subunit -
LXM90_RS29790 (LXM90_29790) 289928..290536 - 609 WP_020094420.1 PAS domain-containing protein -
LXM90_RS29795 (LXM90_29795) 290751..290990 + 240 WP_026605131.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LXM90_RS29800 (LXM90_29800) 290995..291441 + 447 WP_020094418.1 type II toxin-antitoxin system VapC family toxin Toxin
LXM90_RS29805 (LXM90_29805) 291495..292106 - 612 WP_020094417.1 TetR/AcrR family transcriptional regulator -
LXM90_RS29810 (LXM90_29810) 292399..293484 + 1086 WP_103986395.1 acetylhydrolase -
LXM90_RS29815 (LXM90_29815) 293570..294133 - 564 WP_026605129.1 TetR/AcrR family transcriptional regulator -
LXM90_RS29820 (LXM90_29820) 294236..295441 + 1206 WP_020094414.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..456912 456912


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-65)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15562.96 Da        Isoelectric Point: 7.9349

>T230475 WP_020094418.1 NZ_CP090350:290995-291441 [Methylobacterium oryzae]
VYLVDTNVLSAGAPTKAVPAVALIDWMDRNSAGLHLSVVTIAEIEDGIAKSRRDGAARKAERLAAWLETLLHLYAAKVLP
IDLAVARHIGGLSDLARGQGHAPGFADLAIAATARCNGWTVLTRNVRHFAPLGVPACDPFVALPADGR

Download         Length: 447 bp

>T230475 NZ_CP124906:2639037-2639177 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8493.75 Da        Isoelectric Point: 7.0104

>AT230475 WP_026605131.1 NZ_CP090350:290751-290990 [Methylobacterium oryzae]
MQEIQLRDAKATLSAVIDQAKQGAPSIITRHGRPEAVLLSFEDWQRLSRVPSFGRLLMAAPVAADDLAPPSGGLRSAEL

Download         Length: 240 bp

>AT230475 NZ_CP124906:c2639035-2638892 [Enterococcus faecalis]
TGCTACAATAGAGATGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I6WGP9

Antitoxin

Source ID Structure

References