Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 990845..991431 Replicon chromosome
Accession NZ_CP090349
Organism Methylobacterium oryzae strain H33R-06

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LXM90_RS04730 Protein ID WP_234081919.1
Coordinates 991129..991431 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1I6SM66
Locus tag LXM90_RS04725 Protein ID WP_056527585.1
Coordinates 990845..991129 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXM90_RS04685 (LXM90_04685) 985933..986343 + 411 WP_020090917.1 phage major tail protein, TP901-1 family -
LXM90_RS04690 (LXM90_04690) 986349..986711 + 363 WP_020090916.1 gene transfer agent family protein -
LXM90_RS04695 (LXM90_04695) 986753..986929 + 177 Protein_925 phage tail assembly chaperone -
LXM90_RS04700 (LXM90_04700) 986939..987517 + 579 WP_020090915.1 phage tail tape measure protein -
LXM90_RS04705 (LXM90_04705) 987536..988453 - 918 WP_020090914.1 TauD/TfdA family dioxygenase -
LXM90_RS04710 (LXM90_04710) 988838..989479 + 642 WP_234081917.1 DUF2460 domain-containing protein -
LXM90_RS04715 (LXM90_04715) 989494..990369 + 876 WP_234081918.1 DUF2163 domain-containing protein -
LXM90_RS04720 (LXM90_04720) 990366..990914 + 549 WP_020090911.1 NlpC/P60 family protein -
LXM90_RS04725 (LXM90_04725) 990845..991129 - 285 WP_056527585.1 putative addiction module antidote protein Antitoxin
LXM90_RS04730 (LXM90_04730) 991129..991431 - 303 WP_234081919.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXM90_RS04735 (LXM90_04735) 991507..995415 + 3909 WP_234081921.1 glycoside hydrolase/phage tail family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 971698..997887 26189


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(5-96)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10929.53 Da        Isoelectric Point: 10.5079

>T230474 WP_234081919.1 NZ_CP090349:c991431-991129 [Methylobacterium oryzae]
VTTILLSDTVRTWLTGLKDHRARARIAARIRSAGLGNFGDAEPVGTGVFEIRIPYGPGFRVYYVRRGEVTYLLLCGGDKS
SQTRDIQRAKSMAASLDGIT

Download         Length: 303 bp

>T230474 NZ_CP124906:2638775-2638918 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10210.67 Da        Isoelectric Point: 4.6310

>AT230474 WP_056527585.1 NZ_CP090349:c991129-990845 [Methylobacterium oryzae]
MRFTPFDASEFLDSEEAIAEYLAAALDDPDPELFIAALGDVAKARGMAQIAREAGVGRESLYKALTPGSKLRYETVRKIM
DVLGVKLTVSTRSS

Download         Length: 285 bp

>AT230474 NZ_CP124906:c2639035-2638851 [Enterococcus faecalis]
TGCTACAATAGAGATGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1I6SM66

References