Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 643472..644003 Replicon chromosome
Accession NZ_CP090349
Organism Methylobacterium oryzae strain H33R-06

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag LXM90_RS03075 Protein ID WP_234081710.1
Coordinates 643472..643768 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag LXM90_RS03080 Protein ID WP_234081712.1
Coordinates 643758..644003 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXM90_RS03040 (LXM90_03040) 639236..639559 + 324 WP_234081699.1 hypothetical protein -
LXM90_RS03045 (LXM90_03045) 639574..639783 + 210 WP_234081702.1 hypothetical protein -
LXM90_RS03050 (LXM90_03050) 640040..641335 - 1296 WP_234081704.1 arsenic transporter -
LXM90_RS03055 (LXM90_03055) 641351..641791 - 441 WP_234082924.1 arsenate reductase (glutaredoxin) -
LXM90_RS03060 (LXM90_03060) 641791..642318 - 528 WP_234081707.1 arsenate reductase ArsC -
LXM90_RS03065 (LXM90_03065) 642311..642673 - 363 WP_234082927.1 metalloregulator ArsR/SmtB family transcription factor -
LXM90_RS03070 (LXM90_03070) 642724..643470 + 747 WP_234081708.1 arsenical resistance protein ArsH -
LXM90_RS03075 (LXM90_03075) 643472..643768 - 297 WP_234081710.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXM90_RS03080 (LXM90_03080) 643758..644003 - 246 WP_234081712.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LXM90_RS03085 (LXM90_03085) 644118..644384 + 267 WP_234081714.1 hypothetical protein -
LXM90_RS03090 (LXM90_03090) 644955..647369 - 2415 WP_234081715.1 S8 family peptidase -
LXM90_RS03095 (LXM90_03095) 647515..648588 - 1074 WP_234081717.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 639236..680337 41101


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-93)

Antitoxin

Antitoxin ParD

(4-71)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11223.59 Da        Isoelectric Point: 9.4524

>T230473 WP_234081710.1 NZ_CP090349:c643768-643472 [Methylobacterium oryzae]
MGNSARARFTPLARSDLEEIWRYTVGQWSADQADRYHQDIVNAATELANGAKIGRAVEVRAGYLKYRVGSHFIFYRRTDA
GIDVIRVLHQRMDTDSHI

Download         Length: 297 bp

>T230473 NZ_CP124906:c2633444-2633151 [Enterococcus faecalis]
ATTGATTTTGATCCTGCTGCAGGTAAAGAAATTCAGAAGAGACGCCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCG
GAAAACCATGTTTGCTGTGATTTGCCCGATTACTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACA
TAGAAACCCAAGGACAAGTAGTGATCTCACAACTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCAT
TTGCCATTAAAAGATATGGCGAAAATTGACCAAATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8698.71 Da        Isoelectric Point: 4.7906

>AT230473 WP_234081712.1 NZ_CP090349:c644003-643758 [Methylobacterium oryzae]
MARNTSISLGDHFAQFIDRQVEGGRYGSASDVVRAGLRLLEEREAKVAALQAALIAGEESGPAEELDSPAFLTEMRAKHG
Q

Download         Length: 246 bp

>AT230473 NZ_CP124906:c2633722-2633492 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GCCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References