Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1824710..1826218 Replicon chromosome
Accession NZ_CP090348
Organism Pseudomonas aeruginosa strain PA8329

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag LXN03_RS08460 Protein ID WP_003119682.1
Coordinates 1824710..1825297 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag LXN03_RS08465 Protein ID WP_003119683.1
Coordinates 1825364..1826218 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXN03_RS08455 (LXN03_08455) 1820965..1824444 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
LXN03_RS08460 (LXN03_08460) 1824710..1825297 + 588 WP_003119682.1 GNAT family protein Toxin
LXN03_RS08465 (LXN03_08465) 1825364..1826218 + 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
LXN03_RS08470 (LXN03_08470) 1826315..1828467 + 2153 Protein_1680 TonB-dependent receptor family protein -
LXN03_RS08475 (LXN03_08475) 1828642..1830516 + 1875 WP_003091605.1 MFS transporter -
LXN03_RS08480 (LXN03_08480) 1830577..1830786 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T230469 WP_003119682.1 NZ_CP090348:1824710-1825297 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T230469 NZ_CP124906:1719717-1720061 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTTTCCCATTCGGATTACATGGAGTTATATAAAATCCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCGGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGACGGGCAATTTAATTATTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAAGAAACTTATTTAAATTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT230469 WP_003119683.1 NZ_CP090348:1825364-1826218 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp

>AT230469 NZ_CP124906:1719368-1719700 [Enterococcus faecalis]
ATGAACCTCTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTCGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTATTTGAAAGGGAG
ATTCGGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References