Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142620..143125 Replicon chromosome
Accession NZ_CP090348
Organism Pseudomonas aeruginosa strain PA8329

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag LXN03_RS00660 Protein ID WP_003121619.1
Coordinates 142620..142901 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag LXN03_RS00665 Protein ID WP_003112628.1
Coordinates 142898..143125 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXN03_RS00635 (LXN03_00635) 137871..139220 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
LXN03_RS00640 (LXN03_00640) 139269..139955 + 687 WP_004351997.1 FadR/GntR family transcriptional regulator -
LXN03_RS00645 (LXN03_00645) 140056..140790 + 735 WP_003117208.1 GntR family transcriptional regulator -
LXN03_RS00650 (LXN03_00650) 140970..141380 + 411 WP_003101225.1 aegerolysin family protein -
LXN03_RS00655 (LXN03_00655) 141412..142320 - 909 WP_003083769.1 LysR family transcriptional regulator -
LXN03_RS00660 (LXN03_00660) 142620..142901 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
LXN03_RS00665 (LXN03_00665) 142898..143125 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
LXN03_RS00670 (LXN03_00670) 143301..143921 - 621 WP_003101226.1 hypothetical protein -
LXN03_RS00675 (LXN03_00675) 144022..144522 + 501 WP_003101228.1 LEA type 2 family protein -
LXN03_RS00680 (LXN03_00680) 144595..144936 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
LXN03_RS00685 (LXN03_00685) 145018..146445 - 1428 WP_003083784.1 GABA permease -
LXN03_RS00690 (LXN03_00690) 146614..148107 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T230468 WP_003121619.1 NZ_CP090348:c142901-142620 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T230468 NZ_CP124906:497381-497497 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT230468 WP_003112628.1 NZ_CP090348:c143125-142898 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT230468 NZ_CP124906:c497613-497408 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References