Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /RES-TIGR02293 |
Location | 43598..44508 | Replicon | plasmid pKPK3-1 |
Accession | NZ_CP090344 | ||
Organism | Klebsiella pneumoniae strain KPK3 |
Toxin (Protein)
Gene name | - | Uniprot ID | A0A663AYG0 |
Locus tag | LXL84_RS27000 | Protein ID | WP_004026354.1 |
Coordinates | 44038..44508 (+) | Length | 157 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A6P1V3Q9 |
Locus tag | LXL84_RS26995 | Protein ID | WP_004026357.1 |
Coordinates | 43598..44041 (+) | Length | 148 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LXL84_RS26970 (LXL84_26940) | 39457..40023 | + | 567 | WP_094818822.1 | type I-E CRISPR-associated protein Cas6/Cse3/CasE | - |
LXL84_RS26975 (LXL84_26945) | 40026..40988 | + | 963 | WP_004902373.1 | DEAD/DEAH box helicase | - |
LXL84_RS26980 (LXL84_26950) | 41332..41553 | - | 222 | WP_004213615.1 | hypothetical protein | - |
LXL84_RS26985 (LXL84_26955) | 41615..42340 | - | 726 | Protein_48 | TonB-dependent receptor | - |
LXL84_RS26990 (LXL84_26960) | 42384..43364 | + | 981 | WP_159205212.1 | IS5-like element ISKpn26 family transposase | - |
LXL84_RS26995 (LXL84_26965) | 43598..44041 | + | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
LXL84_RS27000 (LXL84_26970) | 44038..44508 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
LXL84_RS27005 (LXL84_26975) | 44657..45354 | + | 698 | WP_223175001.1 | IS1-like element IS1A family transposase | - |
LXL84_RS27010 (LXL84_26980) | 45356..45805 | + | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
LXL84_RS27015 (LXL84_26985) | 45822..46133 | + | 312 | WP_011251282.1 | hypothetical protein | - |
LXL84_RS27020 (LXL84_26990) | 46147..46488 | + | 342 | WP_011251281.1 | hypothetical protein | - |
LXL84_RS27025 (LXL84_26995) | 46548..47504 | + | 957 | WP_011251280.1 | DsbA family protein | - |
LXL84_RS27030 (LXL84_27000) | 47929..48369 | - | 441 | WP_011251275.1 | hypothetical protein | - |
LXL84_RS27035 (LXL84_27005) | 48375..48869 | - | 495 | WP_011251274.1 | hypothetical protein | - |
LXL84_RS27040 (LXL84_27010) | 48878..49192 | - | 315 | WP_011251273.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | - | rmpA2 / iutA / iucD / iucC / iucB / iucA / iroN | 1..189486 | 189486 | |
- | inside | IScluster/Tn | - | iroN | 38377..50789 | 12412 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T230458 WP_004026354.1 NZ_CP090344:44038-44508 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T230458 NZ_CP124901:2740830-2740973 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT230458 WP_004026357.1 NZ_CP090344:43598-44041 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT230458 NZ_CP124901:c2740736-2740535 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGCGCAATCAAAGCAATGGTAAACATACCAA
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGCGCAATCAAAGCAATGGTAAACATACCAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A663AYG0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6P1V3Q9 |