Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5017029..5018710 Replicon chromosome
Accession NZ_CP090343
Organism Klebsiella pneumoniae strain KPK3

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag LXL84_RS24850 Protein ID WP_002885155.1
Coordinates 5017029..5017946 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag LXL84_RS24855 Protein ID WP_004151732.1
Coordinates 5017952..5018710 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXL84_RS24830 (LXL84_24800) 5012335..5013855 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
LXL84_RS24835 (LXL84_24805) 5013852..5014850 + 999 WP_002885172.1 ribose ABC transporter permease -
LXL84_RS24840 (LXL84_24810) 5014881..5015822 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
LXL84_RS24845 (LXL84_24815) 5015897..5016904 + 1008 WP_004151731.1 carbohydrate kinase family protein -
LXL84_RS24850 (LXL84_24820) 5017029..5017946 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LXL84_RS24855 (LXL84_24825) 5017952..5018710 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
LXL84_RS24860 (LXL84_24830) 5018796..5019524 - 729 WP_002885152.1 response regulator transcription factor -
LXL84_RS24865 (LXL84_24835) 5019797..5021944 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
LXL84_RS24870 (LXL84_24840) 5022174..5022860 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T230455 WP_002885155.1 NZ_CP090343:c5017946-5017029 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T230455 NZ_CP124901:2740161-2740343 [Enterococcus faecalis]
ATGGCGGTGGCTATCCAATCTGAAAGAGAGGTGATGCGTATGCACGTATTTCCGAAATTTAGAGAAAGGAGAGGCCTTTT
GTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGC
TTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT230455 WP_004151732.1 NZ_CP090343:c5018710-5017952 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT230455 NZ_CP124901:c2740460-2740276 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References