Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4860845..4861361 Replicon chromosome
Accession NZ_CP090343
Organism Klebsiella pneumoniae strain KPK3

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LXL84_RS24050 Protein ID WP_002886902.1
Coordinates 4860845..4861129 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LXL84_RS24055 Protein ID WP_002886901.1
Coordinates 4861119..4861361 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXL84_RS24025 (LXL84_23995) 4856329..4856592 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LXL84_RS24030 (LXL84_24000) 4856722..4856895 + 174 WP_002886906.1 hypothetical protein -
LXL84_RS24035 (LXL84_24005) 4856898..4857641 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LXL84_RS24040 (LXL84_24010) 4857998..4860136 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
LXL84_RS24045 (LXL84_24015) 4860377..4860841 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LXL84_RS24050 (LXL84_24020) 4860845..4861129 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXL84_RS24055 (LXL84_24025) 4861119..4861361 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LXL84_RS24060 (LXL84_24030) 4861439..4863349 - 1911 WP_004152270.1 PRD domain-containing protein -
LXL84_RS24065 (LXL84_24035) 4863372..4864526 - 1155 WP_002886900.1 lactonase family protein -
LXL84_RS24070 (LXL84_24040) 4864592..4865332 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T230454 WP_002886902.1 NZ_CP090343:c4861129-4860845 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T230454 NZ_CP124901:c2734973-2734632 [Enterococcus faecalis]
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGCCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTTCCACTCGATATACGTTGCCCGATGACATAGAAACCCATGGGCAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT230454 WP_002886901.1 NZ_CP090343:c4861361-4861119 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT230454 NZ_CP124901:c2735203-2734973 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACATTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References