Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4756896..4757706 Replicon chromosome
Accession NZ_CP090343
Organism Klebsiella pneumoniae strain KPK3

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag LXL84_RS23555 Protein ID WP_002887280.1
Coordinates 4756896..4757429 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag LXL84_RS23560 Protein ID WP_002887278.1
Coordinates 4757440..4757706 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXL84_RS23550 (LXL84_23525) 4755727..4756848 + 1122 WP_002887282.1 cupin domain-containing protein -
LXL84_RS23555 (LXL84_23530) 4756896..4757429 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
LXL84_RS23560 (LXL84_23535) 4757440..4757706 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
LXL84_RS23565 (LXL84_23540) 4757809..4759242 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
LXL84_RS23570 (LXL84_23545) 4759232..4759915 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
LXL84_RS23575 (LXL84_23550) 4760087..4761472 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
LXL84_RS23580 (LXL84_23555) 4761490..4761834 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T230453 WP_002887280.1 NZ_CP090343:c4757429-4756896 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T230453 NZ_CP124901:c2598338-2598237 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAACCCTTGTTGCGTTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT230453 WP_002887278.1 NZ_CP090343:c4757706-4757440 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT230453 NZ_CP124901:2598113-2598300 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAACGCAACAAGGGTTGCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References