Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4141795..4142414 Replicon chromosome
Accession NZ_CP090343
Organism Klebsiella pneumoniae strain KPK3

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LXL84_RS20595 Protein ID WP_002892050.1
Coordinates 4142196..4142414 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LXL84_RS20590 Protein ID WP_002892066.1
Coordinates 4141795..4142169 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXL84_RS20580 (LXL84_20555) 4136947..4138140 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LXL84_RS20585 (LXL84_20560) 4138163..4141309 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
LXL84_RS20590 (LXL84_20565) 4141795..4142169 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LXL84_RS20595 (LXL84_20570) 4142196..4142414 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LXL84_RS20600 (LXL84_20575) 4142573..4143139 + 567 WP_002892030.1 maltose O-acetyltransferase -
LXL84_RS20605 (LXL84_20580) 4143111..4143251 - 141 WP_004147370.1 hypothetical protein -
LXL84_RS20610 (LXL84_20585) 4143272..4143742 + 471 WP_002892026.1 YlaC family protein -
LXL84_RS20615 (LXL84_20590) 4143717..4145168 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LXL84_RS20620 (LXL84_20595) 4145269..4145967 + 699 WP_002892021.1 GNAT family protein -
LXL84_RS20625 (LXL84_20600) 4145964..4146104 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LXL84_RS20630 (LXL84_20605) 4146104..4146367 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T230452 WP_002892050.1 NZ_CP090343:4142196-4142414 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T230452 NZ_CP124901:c2597904-2597803 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACAATAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT230452 WP_002892066.1 NZ_CP090343:4141795-4142169 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT230452 NZ_CP124901:2597684-2597858 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAA
TCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References