Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
| Location | 3327919..3328550 | Replicon | chromosome |
| Accession | NZ_CP090343 | ||
| Organism | Klebsiella pneumoniae strain KPK3 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A1Q8YTV3 |
| Locus tag | LXL84_RS16675 | Protein ID | WP_012542177.1 |
| Coordinates | 3328374..3328550 (-) | Length | 59 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A3Q9U6R4 |
| Locus tag | LXL84_RS16670 | Protein ID | WP_017898984.1 |
| Coordinates | 3327919..3328326 (-) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LXL84_RS16635 (LXL84_16615) | 3323283..3323717 | - | 435 | WP_012542168.1 | phage terminase small subunit P27 family | - |
| LXL84_RS16640 (LXL84_16620) | 3323965..3324396 | - | 432 | WP_023279521.1 | hypothetical protein | - |
| LXL84_RS16645 (LXL84_16625) | 3324393..3324710 | - | 318 | WP_023279522.1 | hypothetical protein | - |
| LXL84_RS16650 (LXL84_16630) | 3324662..3325024 | - | 363 | WP_014228901.1 | HNH endonuclease | - |
| LXL84_RS16655 (LXL84_16635) | 3326149..3326499 | - | 351 | WP_017898986.1 | hypothetical protein | - |
| LXL84_RS16660 (LXL84_16640) | 3326496..3326993 | - | 498 | WP_023279523.1 | lysozyme | - |
| LXL84_RS16665 (LXL84_16645) | 3326993..3327208 | - | 216 | WP_017880269.1 | class II holin family protein | - |
| LXL84_RS16670 (LXL84_16650) | 3327919..3328326 | - | 408 | WP_017898984.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LXL84_RS16675 (LXL84_16655) | 3328374..3328550 | - | 177 | WP_012542177.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LXL84_RS16680 (LXL84_16660) | 3328914..3330698 | + | 1785 | WP_032415155.1 | ATP-binding protein | - |
| LXL84_RS16685 (LXL84_16665) | 3330718..3331752 | + | 1035 | WP_219071718.1 | DNA cytosine methyltransferase | - |
| LXL84_RS16690 (LXL84_16670) | 3331777..3332118 | - | 342 | WP_017898982.1 | antiterminator Q family protein | - |
| LXL84_RS16695 (LXL84_16675) | 3332131..3333162 | - | 1032 | WP_071058942.1 | DUF968 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3294450..3347579 | 53129 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6632.83 Da Isoelectric Point: 11.0174
>T230451 WP_012542177.1 NZ_CP090343:c3328550-3328374 [Klebsiella pneumoniae]
VKQSELRRWLAAQGAEFKDGTNHLKIYLNGKQTVMPRHPGKEIPEPLRKAILKQLGIK
VKQSELRRWLAAQGAEFKDGTNHLKIYLNGKQTVMPRHPGKEIPEPLRKAILKQLGIK
Download Length: 177 bp
>T230451 NZ_CP124901:2456567-2456911 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATAATGTGGAGTTAGTTTTTGCTCCAATAAATAAGCGCGCGTGTTACGA
GTCGGTCAAAAGGATAATTTTCGTAAACCAAAATTTATCTATCGAAGAACAAGAAGAAGCTATATTCCATGAGTTTAAAC
ATGTGGTTTCCCATTCGGATTACATGGAGTTATACAACATCCCTTCTTTTAGAAATAAAATGGAAGCTGAGGCAGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGACGGGCAATTTAATTACTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAGGAAACTTATTTAAAATAA
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATAATGTGGAGTTAGTTTTTGCTCCAATAAATAAGCGCGCGTGTTACGA
GTCGGTCAAAAGGATAATTTTCGTAAACCAAAATTTATCTATCGAAGAACAAGAAGAAGCTATATTCCATGAGTTTAAAC
ATGTGGTTTCCCATTCGGATTACATGGAGTTATACAACATCCCTTCTTTTAGAAATAAAATGGAAGCTGAGGCAGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGACGGGCAATTTAATTACTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAGGAAACTTATTTAAAATAA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14959.96 Da Isoelectric Point: 4.4277
>AT230451 WP_017898984.1 NZ_CP090343:c3328326-3327919 [Klebsiella pneumoniae]
MRYPVIFEHDETGWAVFFPDIPEAMTGGETREEALEMAQDALVTAFDFYFDDRREIPAPSAEGDAFVEVPASVAAKVLLL
NRLVSTNTSNADLARLINTRPQEVQRIVSLGHSTKIDTIQKALSALGQKMEIVVH
MRYPVIFEHDETGWAVFFPDIPEAMTGGETREEALEMAQDALVTAFDFYFDDRREIPAPSAEGDAFVEVPASVAAKVLLL
NRLVSTNTSNADLARLINTRPQEVQRIVSLGHSTKIDTIQKALSALGQKMEIVVH
Download Length: 408 bp
>AT230451 NZ_CP124901:2456217-2456549 [Enterococcus faecalis]
ATGAACCTTTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTCGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTACTTAAAAGGAAG
ATTCGGAAAATAA
ATGAACCTTTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTCGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTACTTAAAAGGAAG
ATTCGGAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1Q8YTV3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3Q9U6R4 |