Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2734447..2736035 Replicon chromosome
Accession NZ_CP090343
Organism Klebsiella pneumoniae strain KPK3

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag LXL84_RS13570 Protein ID WP_004199851.1
Coordinates 2734447..2735769 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LXL84_RS13575 Protein ID WP_002904790.1
Coordinates 2735769..2736035 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXL84_RS13555 (LXL84_13535) 2729512..2732013 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
LXL84_RS13560 (LXL84_13540) 2732001..2733005 + 1005 WP_004199852.1 fimbrial protein -
LXL84_RS13565 (LXL84_13545) 2733138..2734430 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LXL84_RS13570 (LXL84_13550) 2734447..2735769 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
LXL84_RS13575 (LXL84_13555) 2735769..2736035 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LXL84_RS13580 (LXL84_13560) 2736301..2736627 - 327 WP_002904788.1 hydroxyisourate hydrolase -
LXL84_RS13585 (LXL84_13565) 2736624..2737124 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LXL84_RS13590 (LXL84_13570) 2737102..2738481 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
LXL84_RS13595 (LXL84_13575) 2738827..2739981 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LXL84_RS13600 (LXL84_13580) 2739962..2740885 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T230450 WP_004199851.1 NZ_CP090343:c2735769-2734447 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T230450 NZ_CP124901:516349-516459 [Enterococcus faecalis]
TTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTTAGCGCT
TGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT230450 WP_002904790.1 NZ_CP090343:c2736035-2735769 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT230450 NZ_CP124901:c516575-516370 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References