Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 878942..879596 Replicon chromosome
Accession NZ_CP090343
Organism Klebsiella pneumoniae strain KPK3

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag LXL84_RS04430 Protein ID WP_004144731.1
Coordinates 879189..879596 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LXL84_RS04425 Protein ID WP_002916312.1
Coordinates 878942..879208 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXL84_RS04400 (LXL84_04400) 874098..875531 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LXL84_RS04405 (LXL84_04405) 875650..876378 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LXL84_RS04410 (LXL84_04410) 876428..876739 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LXL84_RS04415 (LXL84_04415) 876903..877562 + 660 WP_002916317.1 hemolysin III family protein -
LXL84_RS04420 (LXL84_04420) 877713..878696 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LXL84_RS04425 (LXL84_04425) 878942..879208 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LXL84_RS04430 (LXL84_04430) 879189..879596 + 408 WP_004144731.1 protein YgfX Toxin
LXL84_RS04435 (LXL84_04435) 879603..880124 - 522 WP_002916308.1 flavodoxin FldB -
LXL84_RS04440 (LXL84_04440) 880225..881121 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LXL84_RS04445 (LXL84_04445) 881144..881857 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LXL84_RS04450 (LXL84_04450) 881863..883596 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T230441 WP_004144731.1 NZ_CP090343:879189-879596 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T230441 NZ_CP124900:c319134-319039 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT230441 WP_002916312.1 NZ_CP090343:878942-879208 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT230441 NZ_CP124900:318939-319004 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References