Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2231359..2231881 Replicon chromosome
Accession NZ_CP090316
Organism Xylella fastidiosa subsp. morus strain Riv16

Toxin (Protein)


Gene name parE Uniprot ID A0A060HA53
Locus tag IUD23_RS10130 Protein ID WP_038229230.1
Coordinates 2231594..2231881 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A060HDF9
Locus tag IUD23_RS10125 Protein ID WP_004085758.1
Coordinates 2231359..2231601 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUD23_RS10095 (IUD23_10095) 2227398..2227814 + 417 WP_038229223.1 IS200/IS605 family transposase -
IUD23_RS10100 (IUD23_10100) 2228220..2229146 + 927 WP_051606204.1 hypothetical protein -
IUD23_RS10105 (IUD23_10105) 2229288..2229614 - 327 WP_004091396.1 DNA-binding protein -
IUD23_RS10110 (IUD23_10110) 2229744..2230064 - 321 WP_004091397.1 type II toxin-antitoxin system RelE/ParE family toxin -
IUD23_RS10115 (IUD23_10115) 2230525..2230815 + 291 WP_038229226.1 BrnT family toxin -
IUD23_RS10120 (IUD23_10120) 2230802..2231107 + 306 WP_004091409.1 BrnA antitoxin family protein -
IUD23_RS10125 (IUD23_10125) 2231359..2231601 + 243 WP_004085758.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
IUD23_RS10130 (IUD23_10130) 2231594..2231881 + 288 WP_038229230.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IUD23_RS10135 (IUD23_10135) 2231969..2232535 + 567 WP_038229232.1 recombinase family protein -
IUD23_RS10140 (IUD23_10140) 2232620..2232877 - 258 WP_038229233.1 hypothetical protein -
IUD23_RS10145 (IUD23_10145) 2233145..2233570 - 426 WP_038229235.1 antirestriction protein -
IUD23_RS10150 (IUD23_10150) 2233694..2234888 - 1195 Protein_1990 DUF5710 domain-containing protein -
IUD23_RS10155 (IUD23_10155) 2234854..2235852 - 999 WP_004085391.1 MBL fold metallo-hydrolase -
IUD23_RS10160 (IUD23_10160) 2235984..2236670 - 687 WP_038229254.1 TIGR02453 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2211955..2234152 22197
- inside IScluster/Tn - - 2226218..2232535 6317


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11163.63 Da        Isoelectric Point: 5.9570

>T230434 WP_038229230.1 NZ_CP090316:2231594-2231881 [Xylella fastidiosa subsp. morus]
MAKSYRLTPLAEADLEEIWFYTFRHWSIEQADSYHRSLVAVFEGLAAGTKQGCPSVLTDFNKYLCGSHVVYFMDYADHLD
IIRILHQRQDTERYL

Download         Length: 288 bp

>T230434 NZ_CP124898:400708-400809 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8774.77 Da        Isoelectric Point: 6.9881

>AT230434 WP_004085758.1 NZ_CP090316:2231359-2231601 [Xylella fastidiosa subsp. morus]
MSRNTSVALGPHFTSFIDAQVQGGRYGTASDVVRAGLRLLEEHETKVKALQDALNVGHQSGEPRPFDSEVFLSRMHTQHG

Download         Length: 243 bp

>AT230434 NZ_CP124898:c400932-400754 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HA53

Antitoxin

Source ID Structure
AlphaFold DB A0A060HDF9

References