230428

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1095412..1095889 Replicon chromosome
Accession NZ_CP090316
Organism Xylella fastidiosa subsp. morus strain Riv16

Toxin (Protein)


Gene name pasB Uniprot ID Q87CA4
Locus tag IUD23_RS05025 Protein ID WP_011097988.1
Coordinates 1095623..1095889 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A7G7TPD2
Locus tag IUD23_RS05020 Protein ID WP_004091377.1
Coordinates 1095412..1095639 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUD23_RS04995 (IUD23_04995) 1091130..1091507 + 378 WP_038228427.1 DUF596 domain-containing protein -
IUD23_RS12220 1091761..1091889 - 129 WP_267959513.1 hypothetical protein -
IUD23_RS05000 (IUD23_05000) 1092043..1093413 + 1371 WP_230577640.1 DUF769 domain-containing protein -
IUD23_RS05005 (IUD23_05005) 1093410..1093784 + 375 WP_038228431.1 hypothetical protein -
IUD23_RS05010 (IUD23_05010) 1093916..1094296 + 381 WP_038228433.1 DUF596 domain-containing protein -
IUD23_RS12225 1094550..1094678 - 129 WP_267959514.1 hypothetical protein -
IUD23_RS05015 (IUD23_05015) 1094888..1095301 - 414 WP_234056426.1 hypothetical protein -
IUD23_RS05020 (IUD23_05020) 1095412..1095639 + 228 WP_004091377.1 DUF6290 family protein Antitoxin
IUD23_RS05025 (IUD23_05025) 1095623..1095889 + 267 WP_011097988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IUD23_RS05030 (IUD23_05030) 1095900..1097294 - 1395 WP_040123316.1 hypothetical protein -
IUD23_RS05055 (IUD23_05055) 1098486..1099247 + 762 WP_004085598.1 Bax inhibitor-1/YccA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1077296..1125280 47984


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10163.79 Da        Isoelectric Point: 10.6086

>T230428 WP_011097988.1 NZ_CP090316:1095623-1095889 [Xylella fastidiosa subsp. morus]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR

Download         Length: 267 bp

>T230428 NZ_CP124894:c2847416-2847075 [Enterococcus faecalis]
ATGAATGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGCAAAGAGAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACGCGATATACGTTGCCCGATGACATAGAAACCCATGGACAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8615.63 Da        Isoelectric Point: 5.0958

>AT230428 WP_004091377.1 NZ_CP090316:1095412-1095639 [Xylella fastidiosa subsp. morus]
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD

Download         Length: 228 bp

>AT230428 NZ_CP124894:c2847646-2847416 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HDH1

Antitoxin

Source ID Structure
AlphaFold DB A0A7G7TPD2

References