230421

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1386376..1387295 Replicon chromosome
Accession NZ_CP090312
Organism Bacillus licheniformis strain NWMCC0046

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag LXN06_RS07035 Protein ID WP_154994986.1
Coordinates 1386549..1387295 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A6C1W1Q1
Locus tag LXN06_RS07030 Protein ID WP_043925301.1
Coordinates 1386376..1386549 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXN06_RS07005 (LXN06_07005) 1381803..1382900 + 1098 WP_234112928.1 mannonate dehydratase -
LXN06_RS07010 (LXN06_07010) 1382876..1383724 + 849 WP_234112930.1 SDR family oxidoreductase -
LXN06_RS07015 (LXN06_07015) 1383751..1384764 + 1014 WP_234112932.1 zinc-binding alcohol dehydrogenase family protein -
LXN06_RS07020 (LXN06_07020) 1384815..1386086 + 1272 WP_154994984.1 MFS transporter -
LXN06_RS07025 (LXN06_07025) 1386149..1386280 - 132 WP_003180875.1 hypothetical protein -
LXN06_RS07030 (LXN06_07030) 1386376..1386549 - 174 WP_043925301.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
LXN06_RS07035 (LXN06_07035) 1386549..1387295 - 747 WP_154994986.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
LXN06_RS07040 (LXN06_07040) 1387405..1388403 - 999 WP_075753239.1 inorganic phosphate transporter -
LXN06_RS07045 (LXN06_07045) 1388416..1389033 - 618 WP_003180884.1 DUF47 domain-containing protein -
LXN06_RS07050 (LXN06_07050) 1389366..1391123 + 1758 WP_154994988.1 gamma-glutamyltransferase -
LXN06_RS07055 (LXN06_07055) 1391260..1391904 + 645 WP_154994990.1 YesL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-57)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29398.84 Da        Isoelectric Point: 4.5417

>T230421 WP_154994986.1 NZ_CP090312:c1387295-1386549 [Bacillus licheniformis]
MLLFYQFLVWLIVLALSLYVAAVWCFEKKLTEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLERKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEEGDD

Download         Length: 747 bp

>T230421 NZ_CP124894:c317829-317734 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCTATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6917.03 Da        Isoelectric Point: 10.8356

>AT230421 WP_043925301.1 NZ_CP090312:c1386549-1386376 [Bacillus licheniformis]
MEPAFQQDQESVKKRLAFKMFKKQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA

Download         Length: 174 bp

>AT230421 NZ_CP124894:317634-317699 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6C1W1Q1

References