230420

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 577358..577994 Replicon chromosome
Accession NZ_CP090312
Organism Bacillus licheniformis strain NWMCC0046

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag LXN06_RS02895 Protein ID WP_003179128.1
Coordinates 577644..577994 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag LXN06_RS02890 Protein ID WP_006638778.1
Coordinates 577358..577639 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXN06_RS02870 (LXN06_02870) 572468..573952 + 1485 WP_234112651.1 PH domain-containing protein -
LXN06_RS02875 (LXN06_02875) 573949..574548 - 600 WP_043926794.1 rhomboid family intramembrane serine protease -
LXN06_RS02880 (LXN06_02880) 574892..575851 + 960 WP_182071071.1 outer membrane lipoprotein carrier protein LolA -
LXN06_RS02885 (LXN06_02885) 576077..577246 + 1170 WP_216931154.1 alanine racemase -
LXN06_RS02890 (LXN06_02890) 577358..577639 + 282 WP_006638778.1 hypothetical protein Antitoxin
LXN06_RS02895 (LXN06_02895) 577644..577994 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
LXN06_RS02900 (LXN06_02900) 578113..578937 + 825 WP_216931156.1 RsbT co-antagonist protein RsbRA -
LXN06_RS02905 (LXN06_02905) 578941..579306 + 366 WP_043926799.1 STAS domain-containing protein -
LXN06_RS02910 (LXN06_02910) 579309..579710 + 402 WP_023857861.1 anti-sigma regulatory factor -
LXN06_RS02915 (LXN06_02915) 579721..580728 + 1008 WP_154999312.1 PP2C family protein-serine/threonine phosphatase -
LXN06_RS02920 (LXN06_02920) 580787..581113 + 327 WP_154999311.1 anti-sigma factor antagonist -
LXN06_RS02925 (LXN06_02925) 581113..581595 + 483 WP_154999310.1 anti-sigma B factor RsbW -
LXN06_RS02930 (LXN06_02930) 581561..582352 + 792 WP_154999319.1 RNA polymerase sigma factor SigB -
LXN06_RS02935 (LXN06_02935) 582349..582948 + 600 WP_182069236.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T230420 WP_003179128.1 NZ_CP090312:577644-577994 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T230420 NZ_CP124893:2794289-2794432 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT230420 WP_006638778.1 NZ_CP090312:577358-577639 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT230420 NZ_CP124893:c2794626-2794364 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References