Detailed information of TA system TA230418

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 2430952..2431499
• Replicon: chromosome
• Accession: NZ_CP090311
• Organism: Pseudomonas kielensis strain 5BT

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LZV00_RS11255
• Protein ID: WP_265538020.1
• Coordinates: 2430952..2431227 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LZV00_RS11260
• Protein ID: WP_265538021.1
• Coordinates: 2431227..2431499 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZV00_RS11245 (LZV00_11215)	2428923..2429285	+	363	WP_265538018.1	hypothetical protein	-
LZV00_RS11250 (LZV00_11220)	2429743..2430762	-	1020	WP_265538019.1	reverse transcriptase/maturase family protein	-
LZV00_RS11255 (LZV00_11225)	2430952..2431227	-	276	WP_265538020.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LZV00_RS11260 (LZV00_11230)	2431227..2431499	-	273	WP_265538021.1	ribbon-helix-helix domain-containing protein	Antitoxin
LZV00_RS11265 (LZV00_11235)	2431521..2431748	-	228	WP_265538022.1	DUF2807 domain-containing protein	-
LZV00_RS11270 (LZV00_11240)	2431729..2432118	-	390	WP_265538023.1	hypothetical protein	-
LZV00_RS11275 (LZV00_11245)	2432669..2433061	-	393	Protein_2216	transposase	-
LZV00_RS11280 (LZV00_11250)	2433378..2433827	+	450	WP_265538024.1	lysozyme	-
LZV00_RS11285 (LZV00_11255)	2433911..2435602	+	1692	WP_265538025.1	phage tail sheath C-terminal domain-containing protein	-
LZV00_RS11290 (LZV00_11260)	2435696..2436459	-	764	Protein_2219	IS30 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2389036..2446140	57104

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (10-47)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10757.34 Da
• Isoelectric Point: 7.2025

>T230418 WP_265538020.1 NZ_CP090311:c2431227-2430952 [Pseudomonas kielensis]
MELKWTSKALSDIARLYEFLAAVNQSAAARTVQQLTAAPITLLENPRIGERLEEFEPRDVRRIQIGHYEMRYEIVNATIY
LLRLWHTREDR

Nucleotide

• Length: 276 bp

>T230418 NZ_CP124893:c2598035-2597934 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10132.47 Da
• Isoelectric Point: 5.6994

>AT230418 WP_265538021.1 NZ_CP090311:c2431499-2431227 [Pseudomonas kielensis]
MATTAKTRSVTAHVPVQLAERVDLMAERLERSKNWIVKQALSAWIDQEEERSRLTREALADVDAGRVIDHQAVQVWADSL
STDTPLPVPR

Nucleotide

• Length: 273 bp

>AT230418 NZ_CP124893:2597811-2597989 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAGTGCAACAA