Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4301368..4301986 Replicon chromosome
Accession NZ_CP090305
Organism Escherichia coli strain Z503

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LXF06_RS20665 Protein ID WP_001291435.1
Coordinates 4301768..4301986 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LXF06_RS20660 Protein ID WP_000344800.1
Coordinates 4301368..4301742 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXF06_RS20650 (4296457) 4296457..4297650 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LXF06_RS20655 (4297673) 4297673..4300822 + 3150 WP_241415702.1 efflux RND transporter permease AcrB -
LXF06_RS20660 (4301368) 4301368..4301742 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LXF06_RS20665 (4301768) 4301768..4301986 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LXF06_RS20670 (4302158) 4302158..4302708 + 551 Protein_4036 maltose O-acetyltransferase -
LXF06_RS20675 (4302824) 4302824..4303294 + 471 WP_000136192.1 YlaC family protein -
LXF06_RS20680 (4303458) 4303458..4305008 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LXF06_RS20685 (4305050) 4305050..4305403 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LXF06_RS20695 (4305782) 4305782..4306093 + 312 WP_000409911.1 MGMT family protein -
LXF06_RS20700 (4306124) 4306124..4306696 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T230415 WP_001291435.1 NZ_CP090305:4301768-4301986 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T230415 NZ_CP124893:395434-395709 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT230415 WP_000344800.1 NZ_CP090305:4301368-4301742 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT230415 NZ_CP124893:395175-395441 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References