Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3234192..3234830 Replicon chromosome
Accession NZ_CP090305
Organism Escherichia coli strain Z503

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag LXF06_RS15575 Protein ID WP_000813794.1
Coordinates 3234192..3234368 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LXF06_RS15580 Protein ID WP_001270286.1
Coordinates 3234414..3234830 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXF06_RS15555 (3229796) 3229796..3231025 - 1230 WP_130068525.1 BenE family transporter YdcO -
LXF06_RS15560 (3231078) 3231078..3231614 + 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
LXF06_RS15565 (3231687) 3231687..3233648 + 1962 WP_001752477.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LXF06_RS15570 (3233740) 3233740..3233970 - 231 WP_000494244.1 YncJ family protein -
LXF06_RS15575 (3234192) 3234192..3234368 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LXF06_RS15580 (3234414) 3234414..3234830 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LXF06_RS15585 (3234909) 3234909..3236315 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
LXF06_RS15590 (3236560) 3236560..3237705 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
LXF06_RS15595 (3237723) 3237723..3238736 + 1014 WP_000220399.1 ABC transporter ATP-binding protein -
LXF06_RS15600 (3238737) 3238737..3239678 + 942 WP_001251313.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3228608..3229756 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T230413 WP_000813794.1 NZ_CP090305:3234192-3234368 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T230413 NZ_CP124892:83772-83882 [Enterococcus faecalis]
GTGTTATTTGTGAAAGATTTAATGTCGTTGGTTATCGCACCGATCTTTGTAGGATTGGTTCTGGAAATGATTTCTCGTGT
GTTGGACGAGGAAGACGATAACCGAAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT230413 WP_001270286.1 NZ_CP090305:3234414-3234830 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT230413 NZ_CP124892:c83986-83922 [Enterococcus faecalis]
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References