Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1836027..1836681 Replicon chromosome
Accession NZ_CP090305
Organism Escherichia coli strain Z503

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag LXF06_RS08825 Protein ID WP_000244777.1
Coordinates 1836274..1836681 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LXF06_RS08820 Protein ID WP_000354046.1
Coordinates 1836027..1836293 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXF06_RS08800 (1831996) 1831996..1833429 - 1434 WP_001753034.1 6-phospho-beta-glucosidase BglA -
LXF06_RS08805 (1833474) 1833474..1833785 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
LXF06_RS08810 (1833949) 1833949..1834608 + 660 WP_000250274.1 hemolysin III family protein -
LXF06_RS08815 (1834804) 1834804..1835784 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
LXF06_RS08820 (1836027) 1836027..1836293 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LXF06_RS08825 (1836274) 1836274..1836681 + 408 WP_000244777.1 protein YgfX Toxin
LXF06_RS08830 (1836721) 1836721..1837242 - 522 WP_001055874.1 flavodoxin FldB -
LXF06_RS08835 (1837354) 1837354..1838250 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LXF06_RS08840 (1838275) 1838275..1838985 + 711 WP_001753033.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LXF06_RS08845 (1838991) 1838991..1840724 + 1734 WP_000813188.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T230402 WP_000244777.1 NZ_CP090305:1836274-1836681 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T230402 NZ_CP124890:c306003-305908 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT230402 WP_000354046.1 NZ_CP090305:1836027-1836293 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT230402 NZ_CP124890:305808-305873 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References