Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1767663..1768261 Replicon chromosome
Accession NZ_CP090305
Organism Escherichia coli strain Z503

Toxin (Protein)


Gene name doc Uniprot ID A0A8T6PRV3
Locus tag LXF06_RS08460 Protein ID WP_053291281.1
Coordinates 1767884..1768261 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID L4J1C0
Locus tag LXF06_RS08455 Protein ID WP_001603498.1
Coordinates 1767663..1767884 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXF06_RS08440 (1763263) 1763263..1763943 + 681 WP_053270475.1 fimbrial assembly chaperone -
LXF06_RS08445 (1763961) 1763961..1766447 + 2487 WP_063101695.1 fimbrial biogenesis outer membrane usher protein -
LXF06_RS08450 (1766459) 1766459..1767478 + 1020 WP_241415754.1 fimbrial protein -
LXF06_RS08455 (1767663) 1767663..1767884 + 222 WP_001603498.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LXF06_RS08460 (1767884) 1767884..1768261 + 378 WP_053291281.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LXF06_RS08465 (1768371) 1768371..1768586 - 216 Protein_1642 transposase -
LXF06_RS08470 (1768772) 1768772..1770034 - 1263 WP_112875661.1 integrase arm-type DNA-binding domain-containing protein -
LXF06_RS08480 (1770413) 1770413..1771120 - 708 WP_000234514.1 DUF554 domain-containing protein -
LXF06_RS08485 (1771273) 1771273..1771356 + 84 WP_211180506.1 protein YqgH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1755211..1770034 14823
- flank IS/Tn - - 1768305..1768586 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13487.28 Da        Isoelectric Point: 6.2257

>T230401 WP_053291281.1 NZ_CP090305:1767884-1768261 [Escherichia coli]
MRHISPEELIAIHDANISRYGGLPGMPDSGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVYDSPELAELTVGAATGEVSVSTVVATLRRLYGTA

Download         Length: 378 bp

>T230401 NZ_CP124889:1838737-1838853 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8190.24 Da        Isoelectric Point: 6.3159

>AT230401 WP_001603498.1 NZ_CP090305:1767663-1767884 [Escherichia coli]
MQSINFRTARSNLTEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDTTNKKLVNR

Download         Length: 222 bp

>AT230401 NZ_CP124889:c1838969-1838764 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB L4J1C0

References