Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4785667..4786243 Replicon chromosome
Accession NZ_CP090304
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ZJUJY

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag LPC12_RS23180 Protein ID WP_001131963.1
Coordinates 4785667..4785954 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag LPC12_RS23185 Protein ID WP_000063142.1
Coordinates 4785941..4786243 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC12_RS23170 (4780777) 4780777..4784286 - 3510 WP_001043485.1 type I restriction-modification system endonuclease -
LPC12_RS23175 (4784484) 4784484..4785398 + 915 WP_000290512.1 restriction endonuclease -
LPC12_RS23180 (4785667) 4785667..4785954 + 288 WP_001131963.1 BrnT family toxin Toxin
LPC12_RS23185 (4785941) 4785941..4786243 + 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
LPC12_RS23190 (4786318) 4786318..4787274 - 957 WP_000187839.1 GTPase -
LPC12_RS23195 (4787285) 4787285..4787488 - 204 WP_000460616.1 YbdD/YjiX family protein -
LPC12_RS23200 (4787583) 4787583..4789733 - 2151 WP_000379927.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T230395 WP_001131963.1 NZ_CP090304:4785667-4785954 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T230395 NZ_CP124889:c275981-275841 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT230395 WP_000063142.1 NZ_CP090304:4785941-4786243 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT230395 NZ_CP124889:275983-276126 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References