Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4691466..4691982 Replicon chromosome
Accession NZ_CP090304
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ZJUJY

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag LPC12_RS22780 Protein ID WP_000220578.1
Coordinates 4691698..4691982 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LPC12_RS22775 Protein ID WP_000212724.1
Coordinates 4691466..4691708 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC12_RS22755 (4686486) 4686486..4687619 + 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -
LPC12_RS22760 (4687603) 4687603..4688721 + 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LPC12_RS22765 (4688718) 4688718..4689458 + 741 WP_000779263.1 KDGP aldolase family protein -
LPC12_RS22770 (4689475) 4689475..4691388 + 1914 WP_001212137.1 BglG family transcription antiterminator -
LPC12_RS22775 (4691466) 4691466..4691708 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LPC12_RS22780 (4691698) 4691698..4691982 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LPC12_RS22785 (4691986) 4691986..4692450 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LPC12_RS22790 (4692571) 4692571..4694709 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LPC12_RS22795 (4695118) 4695118..4696770 - 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T230394 WP_000220578.1 NZ_CP090304:4691698-4691982 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T230394 NZ_CP124889:c275981-275841 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT230394 WP_000212724.1 NZ_CP090304:4691466-4691708 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT230394 NZ_CP124889:275710-275908 [Enterococcus faecalis]
TTTTTAGGTAATTGTGCTATAATGGTAATGAAAAGAGAGCTATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References