Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3837748..3838508 Replicon chromosome
Accession NZ_CP090304
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ZJUJY

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag LPC12_RS18755 Protein ID WP_000533909.1
Coordinates 3837748..3838233 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LPC12_RS18760 Protein ID WP_000965886.1
Coordinates 3838221..3838508 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC12_RS18725 (3832818) 3832818..3833480 + 663 WP_000747548.1 OmpA family lipoprotein -
LPC12_RS18730 (3833699) 3833699..3834673 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
LPC12_RS18735 (3834723) 3834723..3835433 - 711 WP_000190524.1 DUF3053 domain-containing protein -
LPC12_RS18740 (3835872) 3835872..3836162 + 291 WP_000455790.1 HTH-type transcriptional regulator -
LPC12_RS18745 (3836451) 3836451..3836663 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LPC12_RS18750 (3836837) 3836837..3837376 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
LPC12_RS18755 (3837748) 3837748..3838233 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
LPC12_RS18760 (3838221) 3838221..3838508 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LPC12_RS18765 (3838686) 3838686..3839153 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
LPC12_RS18770 (3839325) 3839325..3839600 - 276 Protein_3673 IS3 family transposase -
LPC12_RS18775 (3839782) 3839782..3841851 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
LPC12_RS18780 (3841861) 3841861..3842772 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
LPC12_RS18785 (3842911) 3842911..3843213 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T230390 WP_000533909.1 NZ_CP090304:c3838233-3837748 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T230390 NZ_CP124887:2761040-2761162 [Enterococcus faecalis]
ATGAAAGGAGTAGGTCTTTTGTCAGCATATGAGACAATTCAGACGATCCTAGGGTTTGGTATGTTTACCATTGCTTTGAT
TGCACTGATTGTGAAATTGCTTAAAGAAGACAAAAAGAAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT230390 WP_000965886.1 NZ_CP090304:c3838508-3838221 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT230390 NZ_CP124887:c2761357-2761095 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCGGGCATCTTTTATTGATGGTCTTTTTAGAGGCGTTGTGCTATAATGG
TAATGAGAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTACTAACGGTGACAAAATTTTAAAGATTTTG
AAATGACCGTCTAACTAGGCAAAGTTAAACAGCGGTCATTTCTTTTTGTCTTCTTTAAGCAATTTCACAATCAGTGCAAT
CAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References