Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 528134..528754 Replicon chromosome
Accession NZ_CP090304
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ZJUJY

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LPC12_RS02395 Protein ID WP_001280991.1
Coordinates 528134..528352 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LPC12_RS02400 Protein ID WP_000344807.1
Coordinates 528380..528754 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC12_RS02355 (523358) 523358..523927 + 570 WP_000779803.1 YbaY family lipoprotein -
LPC12_RS02360 (523960) 523960..524349 - 390 WP_000961285.1 MGMT family protein -
LPC12_RS02370 (524580) 524580..526130 - 1551 WP_000213139.1 EAL domain-containing protein -
LPC12_RS02375 (526355) 526355..526615 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LPC12_RS02380 (526621) 526621..526761 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LPC12_RS02385 (526817) 526817..527287 - 471 WP_000136181.1 YlaC family protein -
LPC12_RS02390 (527404) 527404..527955 - 552 WP_001278792.1 maltose O-acetyltransferase -
LPC12_RS02395 (528134) 528134..528352 - 219 WP_001280991.1 HHA domain-containing protein Toxin
LPC12_RS02400 (528380) 528380..528754 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LPC12_RS02405 (529250) 529250..532399 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LPC12_RS02410 (532422) 532422..533615 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T230375 WP_001280991.1 NZ_CP090304:c528352-528134 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T230375 NZ_CP124886:c2659221-2659078 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT230375 WP_000344807.1 NZ_CP090304:c528754-528380 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT230375 NZ_CP124886:2658958-2659145 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGT
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References