Detailed information of TA system TA230371

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 5432280..5433099
• Replicon: chromosome
• Accession: NZ_CP090245
• Organism: Klebsiella oxytoca strain KONSF-1

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: LXH16_RS25570
• Protein ID: WP_004110819.1
• Coordinates: 5432842..5433099 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: LXH16_RS25565
• Protein ID: WP_234283967.1
• Coordinates: 5432280..5432831 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXH16_RS25545 (LXH16_25545)	5427609..5429006	+	1398	WP_077257937.1	MFS transporter	-
LXH16_RS25550 (LXH16_25550)	5429130..5430470	+	1341	WP_234283966.1	carbohydrate porin	-
LXH16_RS25555 (LXH16_25555)	5430634..5431398	-	765	WP_224238718.1	class I SAM-dependent methyltransferase	-
LXH16_RS25560 (LXH16_25560)	5431792..5432166	-	375	Protein_5008	class I SAM-dependent methyltransferase	-
LXH16_RS25565 (LXH16_25565)	5432280..5432831	-	552	WP_234283967.1	N-acetyltransferase	Antitoxin
LXH16_RS25570 (LXH16_25570)	5432842..5433099	-	258	WP_004110819.1	YjhX family toxin	Toxin
LXH16_RS25575 (LXH16_25575)	5433681..5434865	+	1185	WP_234283968.1	mannonate dehydratase	-
LXH16_RS25580 (LXH16_25580)	5434940..5436415	+	1476	WP_004110817.1	fructuronate reductase	-
LXH16_RS25585 (LXH16_25585)	5436551..5437327	+	777	WP_004099223.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (17-130)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T230371 WP_004110819.1 NZ_CP090245:c5433099-5432842 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T230371 NZ_CP124886:418177-418485 [Enterococcus faecalis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGACAACCAGGATCAGGGAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAAACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACTCTATGAAAAAGACGTAGTAAAACATGCAACATCCTATTCTAATCAGCTGGTAAAGCTTAATTAG

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20110.93 Da
• Isoelectric Point: 6.8798

>AT230371 WP_234283967.1 NZ_CP090245:c5432831-5432280 [Klebsiella oxytoca]
MTNHNFTFHITSERDADDIREVETRAFGFSKEADLVADLLNDESAHPSLSLLAKHNGKAVGHILFTLATFKGESDSPMMH
ILAPLAVVPEYQGVGVGGLLIQRGIEHLKAAGSEAVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPGEHKACWMLQRLSS
RPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT230371 NZ_CP124886:417903-418175 [Enterococcus faecalis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGGGTATTAAA
TTATGTTTTGAATCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGACAAAAGAGAAAGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2