230370

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 5198616..5199235 Replicon chromosome
Accession NZ_CP090245
Organism Klebsiella oxytoca strain KONSF-1

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag LXH16_RS24460 Protein ID WP_004099646.1
Coordinates 5199017..5199235 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag LXH16_RS24455 Protein ID WP_004099648.1
Coordinates 5198616..5198990 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH16_RS24445 (LXH16_24445) 5193772..5194965 + 1194 WP_004111040.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LXH16_RS24450 (LXH16_24450) 5194988..5198134 + 3147 WP_196557707.1 multidrug efflux RND transporter permease subunit AcrB -
LXH16_RS24455 (LXH16_24455) 5198616..5198990 + 375 WP_004099648.1 Hha toxicity modulator TomB Antitoxin
LXH16_RS24460 (LXH16_24460) 5199017..5199235 + 219 WP_004099646.1 HHA domain-containing protein Toxin
LXH16_RS24465 (LXH16_24465) 5199396..5199962 + 567 WP_023320460.1 maltose O-acetyltransferase -
LXH16_RS24470 (LXH16_24470) 5199931..5200068 - 138 WP_224226357.1 hypothetical protein -
LXH16_RS24475 (LXH16_24475) 5200099..5200569 + 471 WP_004111038.1 YlaC family protein -
LXH16_RS24480 (LXH16_24480) 5200544..5201998 - 1455 WP_195606125.1 PLP-dependent aminotransferase family protein -
LXH16_RS24485 (LXH16_24485) 5202100..5202798 + 699 WP_004099639.1 GNAT family protein -
LXH16_RS24490 (LXH16_24490) 5202795..5202935 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LXH16_RS24495 (LXH16_24495) 5202935..5203198 - 264 WP_064396976.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T230370 WP_004099646.1 NZ_CP090245:5199017-5199235 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T230370 NZ_CP124885:62637-62747 [Enterococcus faecalis]
GTGTTATTTGTGAAAGATTTAATGTCGTTGGTTATCGCACCGATCTTTGTAGGATTGGTTCTGGAAATGATTTCTCGTGT
GTTGGACGAGGAAGACGATAACCGAAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT230370 WP_004099648.1 NZ_CP090245:5198616-5198990 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLVTQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT230370 NZ_CP124885:c62851-62787 [Enterococcus faecalis]
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure

References