Detailed information of TA system TA230369

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4400715..4401498
• Replicon: chromosome
• Accession: NZ_CP090245
• Organism: Klebsiella oxytoca strain KONSF-1

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: LXH16_RS20860
• Protein ID: WP_164852945.1
• Coordinates: 4401130..4401498 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: LXH16_RS20855
• Protein ID: WP_049094917.1
• Coordinates: 4400715..4401074 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXH16_RS20810 (LXH16_20810)	4395974..4396651	+	678	WP_004139645.1	WYL domain-containing protein	-
LXH16_RS20815 (LXH16_20815)	4396749..4397378	+	630	WP_142468743.1	hypothetical protein	-
LXH16_RS20820 (LXH16_20820)	4397452..4397925	+	474	WP_049094923.1	hypothetical protein	-
LXH16_RS20825 (LXH16_20825)	4398035..4398247	+	213	WP_049094922.1	hypothetical protein	-
LXH16_RS20830 (LXH16_20830)	4398354..4399175	+	822	WP_049094921.1	DUF932 domain-containing protein	-
LXH16_RS20835 (LXH16_20835)	4399255..4399734	+	480	WP_224240015.1	antirestriction protein	-
LXH16_RS20840 (LXH16_20840)	4399745..4399978	+	234	WP_049094920.1	hypothetical protein	-
LXH16_RS20845 (LXH16_20845)	4399975..4400457	+	483	WP_049094919.1	DNA repair protein RadC	-
LXH16_RS20850 (LXH16_20850)	4400471..4400692	+	222	WP_049094918.1	DUF987 domain-containing protein	-
LXH16_RS20855 (LXH16_20855)	4400715..4401074	+	360	WP_049094917.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
LXH16_RS20860 (LXH16_20860)	4401130..4401498	+	369	WP_164852945.1	TA system toxin CbtA family protein	Toxin
LXH16_RS20865 (LXH16_20865)	4401578..4402033	-	456	WP_224240016.1	hypothetical protein	-
LXH16_RS20870 (LXH16_20870)	4402037..4403026	-	990	WP_234283822.1	glycosyltransferase	-
LXH16_RS20875 (LXH16_20875)	4403792..4404700	-	909	WP_049094914.1	kdo(2)-lipid IV(A) palmitoleoyltransferase	-
LXH16_RS20880 (LXH16_20880)	4404903..4405175	-	273	WP_170833537.1	hypothetical protein	-
LXH16_RS20885 (LXH16_20885)	4405585..4405818	+	234	WP_004132711.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4381942..4405818	23876

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (7-110)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13672.62 Da
• Isoelectric Point: 9.0625

>T230369 WP_164852945.1 NZ_CP090245:4401130-4401498 [Klebsiella oxytoca]
IQSLPPQRAASSRLSSVEIWQKLLEYLLEQHYGLTLNNTPFCNDSVIQKHIDAGISLCDAVNFIVEKYDLVRTDRHGFSV
KEQSPFIGSIDMLRARKATGLMPRKGYQTVTDITSGRFSGGK

Nucleotide

• Length: 369 bp

>T230369 NZ_CP124884:2779654-2779797 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13358.40 Da
• Isoelectric Point: 7.3727

>AT230369 WP_049094917.1 NZ_CP090245:4400715-4401074 [Klebsiella oxytoca]
MQKATRVINHNIAEPWWGLRRNITPCFGARLVQEGNHLHYLADRASIAGTFSDADLRHLDQAFPVVMKQMELMLTSNELT
PHIQRCITFHAKGLICEADTLGSCGYLYIVIYPTSATTA

Nucleotide

• Length: 360 bp

>AT230369 NZ_CP124884:c2779991-2779729 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA