Detailed information of TA system TA230360

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1698371..1699028
• Replicon: chromosome
• Accession: NZ_CP090245
• Organism: Klebsiella oxytoca strain KONSF-1

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LXH16_RS08010
• Protein ID: WP_064370303.1
• Coordinates: 1698618..1699028 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A285B945
• Locus tag: LXH16_RS08005
• Protein ID: WP_004105561.1
• Coordinates: 1698371..1698637 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXH16_RS07990 (LXH16_07990)	1693624..1694049	-	426	WP_004124962.1	PTS sugar transporter subunit IIA	-
LXH16_RS07995 (LXH16_07995)	1694170..1696968	-	2799	WP_016809675.1	transcriptional regulator DagR	-
LXH16_RS08000 (LXH16_08000)	1697144..1698127	-	984	WP_004115279.1	tRNA-modifying protein YgfZ	-
LXH16_RS08005 (LXH16_08005)	1698371..1698637	+	267	WP_004105561.1	FAD assembly factor SdhE	Antitoxin
LXH16_RS08010 (LXH16_08010)	1698618..1699028	+	411	WP_064370303.1	protein YgfX	Toxin
LXH16_RS08015 (LXH16_08015)	1699037..1699558	-	522	WP_004105557.1	flavodoxin FldB	-
LXH16_RS08020 (LXH16_08020)	1699680..1700576	+	897	WP_004105555.1	site-specific tyrosine recombinase XerD	-
LXH16_RS08025 (LXH16_08025)	1700599..1701312	+	714	WP_004105554.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LXH16_RS08030 (LXH16_08030)	1701318..1703051	+	1734	WP_004105553.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16091.86 Da
• Isoelectric Point: 10.9455

>T230360 WP_064370303.1 NZ_CP090245:1698618-1699028 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDTGEWRDLRRLVLQKPTQD

Nucleotide

• Length: 411 bp

>T230360 NZ_CP124884:585396-585512 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGTTGGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10555.02 Da
• Isoelectric Point: 5.1498

>AT230360 WP_004105561.1 NZ_CP090245:1698371-1698637 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT230360 NZ_CP124884:c585628-585423 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Structures

Antitoxin

• AlphaFold DB: A0A285B945