Detailed information of TA system TA023036

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 3100208..3100810
• Replicon: chromosome
• Accession: NC_011146
• Organism: Geobacter bemidjiensis Bem

Toxin (Protein)

• Gene name: relE
• Uniprot ID: E1P6B8
• Locus tag: GBEM_RS13360
• Protein ID: WP_012531106.1
• Coordinates: 3100208..3100504 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E1P6B9
• Locus tag: GBEM_RS13365
• Protein ID: WP_012531107.1
• Coordinates: 3100508..3100810 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GBEM_RS13340	3095799..3096488	+	690	WP_012531102.1	response regulator transcription factor	-
GBEM_RS13345	3096485..3097843	+	1359	WP_012531103.1	HAMP domain-containing protein	-
GBEM_RS13350	3097892..3099130	+	1239	WP_012531104.1	cytochrome c	-
GBEM_RS13355	3099206..3099934	+	729	WP_012531105.1	hypothetical protein	-
GBEM_RS13360	3100208..3100504	+	297	WP_012531106.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GBEM_RS13365	3100508..3100810	+	303	WP_012531107.1	putative addiction module antidote protein	Antitoxin
GBEM_RS21270	3101264..3101767	+	504	WP_148212916.1	hypothetical protein	-
GBEM_RS13375	3102273..3103598	-	1326	WP_041263268.1	hypothetical protein	-
GBEM_RS13380	3103888..3105219	-	1332	WP_041263270.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (4-94)

Antitoxin

• Uncharacterized protein HI1420 (12-98)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11279.03 Da
• Isoelectric Point: 9.9449

>T23036 WP_012531106.1 NC_011146:3100208-3100504 [Geobacter bemidjiensis Bem]
MYIVKTLPEFDAWLNGVKDRTTRLRLARRLDKVQRGNLGDVKPVGRGVFEMREFFGSGWRMYYVERDKVLIVMLGGGDKS
TQTADIAIALERADRLED

Nucleotide

• Length: 297 bp

>T23036 NC_011146:3100208-3100504 [Geobacter bemidjiensis Bem]
ATGTATATCGTGAAAACGCTGCCTGAATTCGATGCCTGGTTAAATGGCGTCAAAGACCGCACCACTCGGTTGCGGCTGGC
TCGCCGCCTTGACAAGGTCCAGCGGGGCAATTTGGGTGACGTGAAACCTGTAGGCCGCGGCGTTTTTGAAATGCGTGAGT
TCTTTGGTTCCGGTTGGCGAATGTACTACGTGGAACGTGACAAAGTCCTTATCGTTATGCTCGGTGGTGGAGACAAATCC
ACACAAACAGCAGATATCGCCATCGCTTTGGAGCGGGCAGACAGATTGGAGGATTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10706.41 Da
• Isoelectric Point: 7.2778

>AT23036 WP_012531107.1 NC_011146:3100508-3100810 [Geobacter bemidjiensis Bem]
MPKKIVVSDLPEFDLATQLKNEADIAAYITMVIEEGDAAELAHALGVAARARGMAEIAQAAGLTREALYKALRPGAHPRF
DTISRVCSALGVRLVAQPRH

Nucleotide

• Length: 303 bp

>AT23036 NC_011146:3100508-3100810 [Geobacter bemidjiensis Bem]
ATGCCGAAAAAAATCGTTGTATCCGACCTGCCGGAATTCGATCTTGCTACACAGCTAAAAAATGAAGCCGACATTGCCGC
GTACATCACCATGGTGATCGAAGAAGGTGACGCAGCAGAGTTGGCCCATGCTTTAGGAGTAGCCGCCCGAGCACGCGGCA
TGGCCGAAATTGCACAAGCTGCGGGGTTGACTAGGGAAGCGCTTTACAAAGCCCTACGTCCTGGAGCTCATCCACGCTTC
GACACGATCAGCAGAGTTTGTTCCGCGCTTGGAGTCCGCCTGGTTGCACAGCCTCGCCATTAG

Structures

Toxin

• AlphaFold DB: E1P6B8

Antitoxin

• AlphaFold DB: E1P6B9