Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 115041..115834 Replicon chromosome
Accession NZ_CP090245
Organism Klebsiella oxytoca strain KONSF-1

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag LXH16_RS00485 Protein ID WP_234284000.1
Coordinates 115041..115430 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag LXH16_RS00490 Protein ID WP_200493555.1
Coordinates 115469..115834 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH16_RS00480 (LXH16_00480) 110259..113774 - 3516 WP_142448058.1 AAA domain-containing protein -
LXH16_RS00485 (LXH16_00485) 115041..115430 - 390 WP_234284000.1 TA system toxin CbtA family protein Toxin
LXH16_RS00490 (LXH16_00490) 115469..115834 - 366 WP_200493555.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LXH16_RS00495 (LXH16_00495) 115860..116081 - 222 WP_200493554.1 DUF987 family protein -
LXH16_RS00500 (LXH16_00500) 116078..116620 - 543 WP_234284001.1 DNA repair protein RadC -
LXH16_RS00505 (LXH16_00505) 116633..117076 - 444 WP_200493552.1 antirestriction protein -
LXH16_RS00510 (LXH16_00510) 117107..117928 - 822 WP_200493551.1 DUF932 domain-containing protein -
LXH16_RS00515 (LXH16_00515) 118027..118251 - 225 WP_200493550.1 DUF905 domain-containing protein -
LXH16_RS00520 (LXH16_00520) 118323..118772 - 450 WP_200493549.1 IrmA family protein -
LXH16_RS00525 (LXH16_00525) 118769..119221 - 453 WP_200493548.1 hypothetical protein -
LXH16_RS00530 (LXH16_00530) 119258..119827 - 570 WP_200493559.1 hypothetical protein -
LXH16_RS00535 (LXH16_00535) 119827..120531 - 705 WP_200493547.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 105610..146710 41100


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(4-112)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14549.65 Da        Isoelectric Point: 9.1643

>T230359 WP_234284000.1 NZ_CP090245:c115430-115041 [Klebsiella oxytoca]
MQKISSHPIRANQPCLSPIEIWQRLLTHLLSQHYGLTLNDTPFSNDSTIQEHIDAGVSLSDAVNFLVEKYELERIDRDGC
TVMEKSPFITSIDILRARKASGLMKRSSHKTVTRVTAGHHQQLKITKGT

Download         Length: 390 bp

>T230359 NZ_CP124884:c317838-317743 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCTATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13561.21 Da        Isoelectric Point: 4.5927

>AT230359 WP_200493555.1 NZ_CP090245:c115834-115469 [Klebsiella oxytoca]
MNNHSESGTTPENPTCQQWGLKSTITPCFGARLVQEDCRIHFLADRAGFNGAFSDNDTLRLDQAFPLMLKQLELMLTSGE
LNPRYQHCVTLYHNGLTCEADTLGSCGYVYIAIYPEQTEPQ

Download         Length: 366 bp

>AT230359 NZ_CP124884:317643-317708 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References