Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4194103..4194772 Replicon chromosome
Accession NZ_CP090244
Organism Serratia marcescens strain SMNSF-1

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag LXH15_RS20130 Protein ID WP_079450550.1
Coordinates 4194103..4194525 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag LXH15_RS20135 Protein ID WP_004931679.1
Coordinates 4194506..4194772 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH15_RS20110 (LXH15_20110) 4189989..4190507 + 519 WP_004931683.1 flavodoxin FldB -
LXH15_RS20115 (LXH15_20115) 4190545..4191909 - 1365 WP_016929973.1 cell envelope integrity protein CreD -
LXH15_RS20120 (LXH15_20120) 4191990..4193408 - 1419 WP_016929974.1 two-component system sensor histidine kinase CreC -
LXH15_RS20125 (LXH15_20125) 4193405..4194103 - 699 WP_016929975.1 two-component system response regulator CreB -
LXH15_RS20130 (LXH15_20130) 4194103..4194525 - 423 WP_079450550.1 protein YgfX Toxin
LXH15_RS20135 (LXH15_20135) 4194506..4194772 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
LXH15_RS20140 (LXH15_20140) 4195093..4196085 + 993 WP_016929977.1 tRNA-modifying protein YgfZ -
LXH15_RS20145 (LXH15_20145) 4196124..4196621 - 498 WP_197759266.1 DUF2165 domain-containing protein -
LXH15_RS20150 (LXH15_20150) 4196772..4197446 - 675 WP_028127690.1 hemolysin III family protein -
LXH15_RS20155 (LXH15_20155) 4197630..4198238 + 609 WP_028127691.1 HD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16531.64 Da        Isoelectric Point: 11.2159

>T230355 WP_079450550.1 NZ_CP090244:c4194525-4194103 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLHPPTGNGEEP

Download         Length: 423 bp

>T230355 NZ_CP124882:c2835796-2835455 [Enterococcus faecalis]
ATGAATGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGATGCCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCAAGGACAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT230355 WP_004931679.1 NZ_CP090244:c4194772-4194506 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT230355 NZ_CP124882:c2836026-2835796 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GCCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References