Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 2228334..2228836 Replicon chromosome
Accession NC_011146
Organism Geobacter bemidjiensis Bem

Toxin (Protein)


Gene name relE Uniprot ID B5EBR6
Locus tag GBEM_RS09650 Protein ID WP_012530359.1
Coordinates 2228334..2228588 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID B5EBR7
Locus tag GBEM_RS09655 Protein ID WP_012530360.1
Coordinates 2228585..2228836 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBEM_RS09635 2224541..2226697 + 2157 WP_083770245.1 hypothetical protein -
GBEM_RS09640 2226900..2227304 + 405 WP_012530357.1 GNAT family N-acetyltransferase -
GBEM_RS21045 2227471..2227626 - 156 Protein_1916 helix-turn-helix transcriptional regulator -
GBEM_RS09645 2227702..2228190 + 489 WP_012530358.1 VOC family protein -
GBEM_RS09650 2228334..2228588 - 255 WP_012530359.1 Txe/YoeB family addiction module toxin Toxin
GBEM_RS09655 2228585..2228836 - 252 WP_012530360.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GBEM_RS09660 2229204..2230262 - 1059 WP_012530361.1 low specificity L-threonine aldolase -
GBEM_RS09665 2230440..2231348 - 909 WP_012530362.1 DMT family transporter -
GBEM_RS09670 2231534..2232280 + 747 WP_012530363.1 basic amino acid ABC transporter substrate-binding protein -
GBEM_RS09675 2232438..2233223 + 786 WP_041262721.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-84)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 10188.67 Da        Isoelectric Point: 9.7162

>T23035 WP_012530359.1 NC_011146:c2228588-2228334 [Geobacter bemidjiensis Bem]
MKLIFSESAWEDYLFWQSTDKKVAKRINTLIREIQRKPHEGIGKPEPLRHALSGYWSRRINDEHRIVYKVEDDSVMIAQL
RYHY

Download         Length: 255 bp

>T23035 NC_011146:c2228588-2228334 [Geobacter bemidjiensis Bem]
TTGAAGCTCATATTCTCGGAAAGCGCTTGGGAAGATTACCTGTTCTGGCAGAGCACAGACAAGAAGGTCGCCAAGCGCAT
CAACACCCTGATCAGGGAGATCCAGAGAAAGCCCCACGAAGGGATAGGGAAACCGGAACCACTGAGGCATGCTCTATCCG
GGTACTGGTCCCGCAGAATCAACGACGAGCATCGCATCGTGTACAAGGTCGAAGATGACTCAGTAATGATCGCGCAGCTT
CGTTACCACTACTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9371.78 Da        Isoelectric Point: 4.8604

>AT23035 WP_012530360.1 NC_011146:c2228836-2228585 [Geobacter bemidjiensis Bem]
MNSITYSSVRSKLAETMEKVCDDHAPVIITRKAAKPVVMMSLDDYEALEETAYLLRSPKNVRRLVESIAELETGKATERE
LID

Download         Length: 252 bp

>AT23035 NC_011146:c2228836-2228585 [Geobacter bemidjiensis Bem]
ATGAATTCGATAACCTACAGTTCCGTGCGCAGCAAACTGGCAGAAACGATGGAGAAGGTATGTGACGACCATGCCCCCGT
CATCATCACCCGCAAAGCGGCAAAGCCGGTGGTCATGATGTCACTTGACGACTACGAAGCGCTGGAGGAAACGGCGTACC
TGCTGCGAAGCCCTAAAAACGTGCGGCGGCTGGTTGAATCTATAGCCGAGCTAGAGACCGGAAAGGCAACCGAACGGGAG
CTGATCGATTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB B5EBR6


Antitoxin

Source ID Structure
AlphaFold DB B5EBR7

References