Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4552776..4553433 Replicon chromosome
Accession NZ_CP090242
Organism Klebsiella pneumoniae strain KPNSF-2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LXH14_RS21880 Protein ID WP_002916310.1
Coordinates 4553023..4553433 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LXH14_RS21875 Protein ID WP_002916312.1
Coordinates 4552776..4553042 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH14_RS21850 (4547984) 4547984..4549417 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LXH14_RS21855 (4549536) 4549536..4550264 - 729 WP_048336809.1 MurR/RpiR family transcriptional regulator -
LXH14_RS21860 (4550314) 4550314..4550625 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LXH14_RS21865 (4550789) 4550789..4551448 + 660 WP_002916317.1 hemolysin III family protein -
LXH14_RS21870 (4551547) 4551547..4552530 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
LXH14_RS21875 (4552776) 4552776..4553042 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LXH14_RS21880 (4553023) 4553023..4553433 + 411 WP_002916310.1 protein YgfX Toxin
LXH14_RS21885 (4553440) 4553440..4553961 - 522 WP_002916308.1 flavodoxin FldB -
LXH14_RS21890 (4554062) 4554062..4554958 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LXH14_RS21895 (4554981) 4554981..4555694 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LXH14_RS21900 (4555700) 4555700..4557433 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T230337 WP_002916310.1 NZ_CP090242:4553023-4553433 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T230337 NZ_CP124873:682965-683306 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTATAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGGACTGGTTCGTATCGACAGGAATGGATTT
GTCTGGCAGGAACAATCACCTTATCTTCGGGCCGTTGATATTCTGCGAGCGCGGCAGGCAACTGGCTTATTGCGACAAAG
CCGTAACAACGCAATACGTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT230337 WP_002916312.1 NZ_CP090242:4552776-4553042 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT230337 NZ_CP124873:682627-682944 [Klebsiella pneumoniae]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATCTGGCTGACCGGGCCAGTATGACCGGTAAATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGATCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCCGTTTACCCCATCCAACGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References