Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3207480..3207996 Replicon chromosome
Accession NZ_CP090242
Organism Klebsiella pneumoniae strain KPNSF-2

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LXH14_RS15315 Protein ID WP_004178374.1
Coordinates 3207480..3207764 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LXH14_RS15320 Protein ID WP_002886901.1
Coordinates 3207754..3207996 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH14_RS15290 (3202876) 3202876..3203139 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LXH14_RS15295 (3203269) 3203269..3203442 + 174 WP_181936711.1 hypothetical protein -
LXH14_RS15300 (3203445) 3203445..3204188 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LXH14_RS15305 (3204545) 3204545..3206683 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LXH14_RS15310 (3207012) 3207012..3207476 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LXH14_RS15315 (3207480) 3207480..3207764 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXH14_RS15320 (3207754) 3207754..3207996 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LXH14_RS15325 (3208074) 3208074..3209984 - 1911 WP_012737231.1 PRD domain-containing protein -
LXH14_RS15330 (3210007) 3210007..3211161 - 1155 WP_012737230.1 lactonase family protein -
LXH14_RS15335 (3211228) 3211228..3211968 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T230333 WP_004178374.1 NZ_CP090242:c3207764-3207480 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T230333 NZ_CP124868:39967-40119 [Klebsiella quasipneumoniae]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT230333 WP_002886901.1 NZ_CP090242:c3207996-3207754 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT230333 NZ_CP124868:c39915-39855 [Klebsiella quasipneumoniae]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References