Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2447791..2448410 Replicon chromosome
Accession NZ_CP090242
Organism Klebsiella pneumoniae strain KPNSF-2

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LXH14_RS11745 Protein ID WP_002892050.1
Coordinates 2448192..2448410 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LXH14_RS11740 Protein ID WP_002892066.1
Coordinates 2447791..2448165 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH14_RS11730 (2442943) 2442943..2444136 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LXH14_RS11735 (2444159) 2444159..2447305 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LXH14_RS11740 (2447791) 2447791..2448165 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LXH14_RS11745 (2448192) 2448192..2448410 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LXH14_RS11750 (2448569) 2448569..2449135 + 567 WP_002892030.1 maltose O-acetyltransferase -
LXH14_RS11755 (2449107) 2449107..2449247 - 141 WP_004147370.1 hypothetical protein -
LXH14_RS11760 (2449268) 2449268..2449738 + 471 WP_002892026.1 YlaC family protein -
LXH14_RS11765 (2449713) 2449713..2451164 - 1452 WP_014907971.1 PLP-dependent aminotransferase family protein -
LXH14_RS11770 (2451265) 2451265..2451963 + 699 WP_002892021.1 GNAT family protein -
LXH14_RS11775 (2451960) 2451960..2452100 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LXH14_RS11780 (2452100) 2452100..2452363 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T230331 WP_002892050.1 NZ_CP090242:2448192-2448410 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T230331 NZ_CP124866:3875381-3875599 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGCCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACGTCCGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT230331 WP_002892066.1 NZ_CP090242:2447791-2448165 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT230331 NZ_CP124866:3874980-3875354 [Klebsiella quasipneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACATCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACGTTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGATACATTTACATTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References