230321

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 5080871..5081393 Replicon chromosome
Accession NZ_CP090222
Organism Klebsiella pneumoniae strain BY11

Toxin (Protein)


Gene name stbE Uniprot ID A0A0C7KG00
Locus tag LVJ01_RS24720 Protein ID WP_038991638.1
Coordinates 5080871..5081155 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag LVJ01_RS24725 Protein ID WP_004181777.1
Coordinates 5081145..5081393 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ01_RS24685 (5076508) 5076508..5076852 + 345 WP_014386518.1 hypothetical protein -
LVJ01_RS24690 (5076849) 5076849..5077220 + 372 WP_044816264.1 hypothetical protein -
LVJ01_RS24695 (5077265) 5077265..5078452 - 1188 WP_043907031.1 RNA-guided endonuclease TnpB family protein -
LVJ01_RS24700 (5078488) 5078488..5078916 + 429 WP_077256229.1 IS200/IS605 family transposase -
LVJ01_RS24705 (5078995) 5078995..5079219 + 225 Protein_4820 transposase -
LVJ01_RS24710 (5079491) 5079491..5080717 - 1227 WP_119355547.1 RNA-guided endonuclease TnpB family protein -
LVJ01_RS24715 (5080753) 5080753..5080854 + 102 Protein_4822 IS200/IS605 family transposase -
LVJ01_RS24720 (5080871) 5080871..5081155 - 285 WP_038991638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVJ01_RS24725 (5081145) 5081145..5081393 - 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LVJ01_RS24730 (5081684) 5081684..5083483 + 1800 WP_043907032.1 ATP-dependent helicase -
LVJ01_RS24735 (5083817) 5083817..5084803 + 987 WP_040120328.1 hypothetical protein -
LVJ01_RS24740 (5084948) 5084948..5085301 + 354 WP_004181774.1 hypothetical protein -
LVJ01_RS24745 (5085363) 5085363..5086184 + 822 WP_004181772.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10993.73 Da        Isoelectric Point: 10.6516

>T230321 WP_038991638.1 NZ_CP090222:c5081155-5080871 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYHLTKHRN

Download         Length: 285 bp

>T230321 NZ_CP124844:c5765-5502 [Aeromonas salmonicida]
TTGGCTTGGAAAGTTGAGTTAACCGATACCGCCAAGAAACAATTGGCGAGGCTAGATAAGACCCAAGCCCAGAGAATAAC
AAAGTATCTTCGTCGGGTTATGTTGCTTGAAGATCCTAGGGATGCAGGTAAAGCCTTGACGGGAAACTTGCGTACCTACT
GGCGATATCGAGTCGGTGATTATCGCGTTGTTTGTGAAATAAGAGATAACGAAATGATTATTGTTGCTGTGATGGTTGGC
CATCGCAGTGATATATACGAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT230321 WP_004181777.1 NZ_CP090222:c5081393-5081145 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT230321 NZ_CP124844:c5973-5749 [Aeromonas salmonicida]
ATGTTAGCGATACGCTTGCCTTCGGATATCGAAGAGCGCTTGGCAAATTTGGCGCAAGAGACGGGGAGAACGAAGACCTT
CTATGCGCGGGAGGCTATCTTGACTCATCTGGAAGAGATGGAAGATTACTATCTGGCCGAAAGGGTCATGGAGAAAGTTC
GTAAGGGCGAAGAACGCCTGTTCTCACTGGATGACGTGGAGCGCGATCTTGGCTTGGAAAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7KG00

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References