230318

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4526317..4526833 Replicon chromosome
Accession NZ_CP090222
Organism Klebsiella pneumoniae strain BY11

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LVJ01_RS22095 Protein ID WP_004178374.1
Coordinates 4526317..4526601 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LVJ01_RS22100 Protein ID WP_002886901.1
Coordinates 4526591..4526833 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ01_RS22070 (4521801) 4521801..4522109 - 309 WP_004178377.1 PTS sugar transporter subunit IIB -
LVJ01_RS22075 (4522194) 4522194..4522367 + 174 WP_032408826.1 hypothetical protein -
LVJ01_RS22080 (4522370) 4522370..4523113 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LVJ01_RS22085 (4523470) 4523470..4525608 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LVJ01_RS22090 (4525849) 4525849..4526313 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LVJ01_RS22095 (4526317) 4526317..4526601 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVJ01_RS22100 (4526591) 4526591..4526833 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LVJ01_RS22105 (4526911) 4526911..4528821 - 1911 WP_004178373.1 PRD domain-containing protein -
LVJ01_RS22110 (4528844) 4528844..4529998 - 1155 WP_004178372.1 lactonase family protein -
LVJ01_RS22115 (4530065) 4530065..4530805 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T230318 WP_004178374.1 NZ_CP090222:c4526601-4526317 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T230318 NZ_CP124841:c1627273-1626620 [Aeromonas salmonicida]
ATGGCCTATGACTATAGCCAGAGCCTGAATCCGGAGAAGGCGTTGATATTCCGGATCGTGCATCGGGATAACCTGGAATG
GATCCTGACCCATGGCCTGTGGGCGGGGAATGGTCAGCAGCAAAACTCGCACTGGGTGCATATCGGGTTGCCGGAGCTGA
TTGCCAAGCGTGCACGCCATCCGGTGCCGCTGGCCCCTTACGGCGTGTTGAATGACTATGTGCCCTTCTACTTCACGCCG
TTTTCTCCCATGCTCAGCAATATTCACTCGGGGCGCGGTGTTCCCCGGCGTGAAAATGATGAAATCCTGATCCTGGTTTC
CAGCCTGCATCGCATGGCTGAACTGGGGCTACCGTTTGTGTTTACCGATAGCCATGCCTATTACCAGTGGGCCAATTTCT
ATGTCGACCTTGGCGATCTGGGGCGGATTGACTGGCCACTGTTGCAGCGCCGTGATTTCAAGCGTGATGCGGAAGATTTG
AGCAAGCTGGAACGCTATCAGGCCGAGGCCTTGATCCATCAACATTGCCCCATCGAGGCGTTGCTGGGCGTGGTGTGTTA
CAACGAAGAGATAAAGAACCGCGTGGAACAATGCATGAATCGGGTGGGGGTCGCGCGCCCCGTCTATGTCCGTGATGGGT
GGTATTTCAGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT230318 WP_002886901.1 NZ_CP090222:c4526833-4526591 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT230318 NZ_CP124841:c1626623-1625559 [Aeromonas salmonicida]
ATGATTCGATATACAACAGGCAATCTGCTGGATGCTCCGGTGGAAGCGCTGGTGAATACCGTCAACACCGTCGGTGTCAT
GGGCAAGGGGATCGCCTTGATGTTCAAGGAGCGGTTCCCGGCCAATATGCGCGCCTATGCCGAGGCGTGCAAACAGGGTG
ATGTCGTCACCGGCAAGATGTTTATTACCCAGACGGGTGAGCTGCTGGGGCCGCGCTGGATCGTGAATTTTCCGACCAAA
CAGCACTGGCGCAATCCGGCACAGATGGCGTGGATCCAGGATGGTTTGCAGGATCTGCGGGCCTGGTTACAGGCGCAGCA
GGTCTCTTCGATTGCCATTCCGCCGCTGGGGGCTGGCAACGGTGGTCTGCCTTGGCCAGAGGTCAAACAGGCGATTGAAA
CGGCACTGGGCGATCTGGATATCGATATCCTGCTCTATGAGCCCAGTAGCCAATACCAAAATGTGGCCAAGCGCGGCGGG
GTGGCGGAGCTGACTCCGGCTCGGGCCCTGATTGCTGAACTGGTACGTCGCTACTGGTTTTTAGGGATGGAGTGCAGCTT
GCTGGAAATCCAGAAGCTGGCCTGGTTTCTGGCTCGGGTCATTGGCCGTAACCCGCTGGGGGATCCGCTGCAGTTGCAGT
TTAAGGCCCATCGTTATGGCCCTTATGCCAACAATCTGACTCATCTGCTCAATGCGATGGACGGCAGTTATCTGCAGTCC
GACAAGCGCATCCCGGATAGCAAGCCGTTTGATGTCATCTGGTTTAATGAGGCCAAAAAACAAGAGCTTGCCGTTTATCT
CCATACCGAGGCCAAAGCATTTTTACCGATACTGGAGCAGACGACCGCGTTAATCGACGGTTTTGAGTCGCCCTATGGCA
TGGAGTTATTGGCCACGGTCGATTGGTTGATAGCCGAAGAGGGCTGTGCGCCGACGCTGAGCGCGCTGCGAGAGGGGTTG
CATCGCTGGCCAGCGGGAACCCCGTGGGGTGAGCGCAAGGCGCGGCTGTTTGATGATCGCAGTCTGCAGATCGCCTTGAC
CCGTTTGCAGCAGGGATTGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References